磺胺二甲嘧啶

Description

SULFAMETHAZINE · CAS 57-68-1 · C12H14N4O2S. UNII 48U51W007F. Melting Point: 387 to 392 °F (NTP, 1992); Melting Point: 198.5; Melting Point: 198.5 °C.

Identification

CAS Registry Number	57-68-1
PubChem CID	5327
Molecular formula	C12H14N4O2S
IUPAC name	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
UNII (FDA)	48U51W007F

Computed Descriptors

Molecular Weight	278.33
XLogP3	0.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	278.08374688
Monoisotopic Mass	278.08374688
Topological Polar Surface Area	106
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	387 to 392 °F (NTP, 1992)
Melting Point	198.5
Melting Point	198.5 °C
Solubility	1500
Solubility	2.30e-01 g/L
Density	1.4655 g/cu cm
LogP	0.89
LogP	log Kow = 0.14
LogP	0.21
Dissociation Constants	7.59

Physical description & handling notes

• Sulfamethazine appears as odorless sticky, white or creamy-white crystalline powder. Slightly bitter taste. An antibacterial.
• Solid
• Crystals from dioxane-water
• Creamy-white powder or crystals from dioxan
• White or yellowish-white powder
• Odorless

Regulatory Status

Regulatory & Food Contact	ANTIMICROBIAL_AGENT: Veterinary Drug JECFA ADI: 0-0.05 mg/kg bw TRS 851-JECFA 42/25 FAS 33-JECFA 42/91 SULFAMIDINE
GHS notification summary	18.8% (9 / 48)

GHS Hazard Classification

GHS notification summary	18.8% (9 / 48)
Reported hazard statements	H315 (75%), H319 (75%)

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Pharmaceuticals -> Antiinfectives for systemic use -> Antibacterials for systemic use -> Sulfonamides and trimethoprims -> Short-acting sulfonamides -> Antibiotics
• (1977) PROBABLY GREATER THAN 1.36X10+6 GRAMS
• (1977) 4.92X10+8 GRAMS (PRINCPL CUSTMS DISTS)

Synonyms

sulfamethazine; Sulfadimidine; 57-68-1; Sulfadimerazine; Sulphamethazine; Sulfamezathine; Sulphadimidine; 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide; Sulfadimethylpyrimidine; Sulfadimezine; Sulfadimethyldiazine; Sulfadimesine; Sulphamezathine; Sulphamidine; Sulfadine; Sulfamethiazine

Frequently Asked Questions

What are the CAS number and molecular formula of SULFAMETHAZINE?

CAS 57-68-1; molecular formula C12H14N4O2S; molecular weight — g/mol.

What other names is SULFAMETHAZINE known by?

sulfamethazine, Sulfadimidine, 57-68-1, Sulfadimerazine, Sulphamethazine, Sulfamezathine.

What is the regulatory status of SULFAMETHAZINE?

Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; JECFA ADI: 0-0.05 mg/kg bw; TRS 851-JECFA 42/25.

Is SULFAMETHAZINE classified as hazardous?

18.8% of GHS notifications report no hazard classification (9 of 48).

What are the key physical properties of SULFAMETHAZINE?

Melting Point: 387 to 392 °F (NTP, 1992); Melting Point: 198.5; Melting Point: 198.5 °C; Solubility: 1500.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.