舒林酸

Description

Sulindac · CAS 38194-50-2 · C20H17FO3S. UNII 184SNS8VUH. Melting Point: 183; Melting Point: 183 °C; Solubility: 3000.

Identification

CAS Registry Number	38194-50-2
PubChem CID	1548887
Molecular formula	C20H17FO3S
IUPAC name	2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
UNII (FDA)	184SNS8VUH

Computed Descriptors

Molecular Weight	356.4
XLogP3	3.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	356.08824374
Monoisotopic Mass	356.08824374
Topological Polar Surface Area	73.6
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	183
Melting Point	183 °C
Solubility	3000
Solubility	2.51e-02 g/L
LogP	3.42
LogP	3.5
LogP	3.29
Dissociation Constants	4.7

Physical description & handling notes

• Solid
• 196.2 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4023624]
• 191.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 192.6 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 168.12 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 190.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	1.3% (1 / 78)

GHS Hazard Classification

GHS notification summary	1.3% (1 / 78)
Reported hazard statements	H301 (97.4%), H317 (52.6%), H319 (44.9%), H334 (52.6%), H360 (44.9%), H361 (52.6%), H373 (44.9%)

Documented Uses

• Consumption (g per capita) in the USA (2002): 0.0201
• For acute or long-term use in the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis.
• Sulindac is classified as a nonsteroidal anti-inflammatory drug (NSAID), exhibiting anti-inflammatory and analgesic properties. Similar to other NSAIDs, sulindac is primarily utilized for the treatment of conditions characterized by acute or chronic inflammation. However, according to the manufacturer, its indications are broad.
• Sulindac is a commonly used nonsteroidal antiinflammatory drug (NSAID) that is available by prescription only and used predominantly to treat chronic arthritis. Sulindac is a rare, but well established cause of idiosyncratic, clinically apparent drug induced liver disease.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents. Nonsteroidal
• Nonsteroidal Antiinflammatory Drugs

Synonyms

sulindac; 38194-50-2; Clinoril; Arthrocine; Artribid; Sulindaco; Sulindacum; Citireuma; Sulindac sulfoxide; Aflodac; Imbaral; Algocetil; Clisundac; Reumofil; Sulinol; Sulreuma

Frequently Asked Questions

What are the CAS number and molecular formula of Sulindac?

CAS 38194-50-2; molecular formula C20H17FO3S; molecular weight — g/mol.

What other names is Sulindac known by?

sulindac, 38194-50-2, Clinoril, Arthrocine, Artribid, Sulindaco.

Is Sulindac classified as hazardous?

1.3% of GHS notifications report no hazard classification (1 of 78).

What are the key physical properties of Sulindac?

Melting Point: 183; Melting Point: 183 °C; Solubility: 3000; Solubility: 2.51e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.