TACRINE HYDROCHLORIDE

Description

TACRINE HYDROCHLORIDE · CAS 1684-40-8 · C13H15ClN2. UNII 4966RNG0BU. Melting Point: 543 to 547 °F (NTP, 1992).

Identification

CAS Registry Number	1684-40-8
PubChem CID	2723754
Molecular formula	C13H15ClN2
IUPAC name	1,2,3,4-tetrahydroacridin-9-amine;hydrochloride
UNII (FDA)	4966RNG0BU

Computed Descriptors

Molecular Weight	234.72
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	234.0923762
Monoisotopic Mass	234.0923762
Topological Polar Surface Area	38.9
Heavy Atom Count	16
Formal Charge	0
Complexity	229

Physical & Chemical Properties

Melting Point	543 to 547 °F (NTP, 1992)

Physical description & handling notes

• 1,2,3,4-tetrahydro-9-aminoacridine hydrochloride monohydrate appears as yellow needles (from concentrated hydrochloric acid); white powder. pH of 1.5% solution: 4.5-6. Bitter taste. (NTP, 1992)
• greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
• 141.4 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H301 (100%), H315 (97.4%), H319 (97.4%), H335 (97.4%)

Documented Uses

• Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
• Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.

Synonyms

Tacrine hydrochloride; 1684-40-8; Tacrine HCl; Hydroaminacrine; Tenakrin; CI-970; NSC-72108; 9-Acridinamine, 1,2,3,4-tetrahydro-, monohydrochloride; 4966RNG0BU; CI 970; 1,2,3,4-Tetrahydro-9-aminoacridine hydrochloride; 9-Amino-1,2,3,4-tetrahydroacridine monohydrochloride; NSC72108; Acridine, 9-amino-1,2,3,4-tetrahydro-, hydrochloride; Acridine, 9-amino-1,2,3,4-tetrahydro-, monohydrochloride; ACRIDINE, 1,2,3,4-TETRAHYDRO-9-AMINO-, MONOHYDROCHLORIDE

Frequently Asked Questions

What are the CAS number and molecular formula of TACRINE HYDROCHLORIDE?

CAS 1684-40-8; molecular formula C13H15ClN2; molecular weight — g/mol.

What other names is TACRINE HYDROCHLORIDE known by?

Tacrine hydrochloride, 1684-40-8, Tacrine HCl, Hydroaminacrine, Tenakrin, CI-970.

Is TACRINE HYDROCHLORIDE classified as hazardous?

Hazard statements reported: H301, H315, H319, H335.

What are the key physical properties of TACRINE HYDROCHLORIDE?

Melting Point: 543 to 547 °F (NTP, 1992).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.