Tenofovir

Description

Tenofovir · CAS 147127-20-6 · C9H14N5O4P. UNII W4HFE001U5. Boiling Point: 616; Melting Point: 279; Melting Point: 276 - 280 °C.

Identification

CAS Registry Number	147127-20-6
PubChem CID	464205
Molecular formula	C9H14N5O4P
IUPAC name	[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
UNII (FDA)	W4HFE001U5

Computed Descriptors

Molecular Weight	287.21
XLogP3	-1.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	287.07834094
Monoisotopic Mass	287.07834094
Topological Polar Surface Area	136
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Boiling Point	616
Melting Point	279
Melting Point	276 - 280 °C
Solubility	13.4
Solubility	1.87e+00 g/L
LogP	-1.6

Physical description & handling notes

• Solid
• 3.8 and 6.7

GHS Hazard Classification

Reported hazard statements	H318 (100%)

Documented Uses

• Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus. To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, [tenofovir alafenamide] and [tenofovir disoproxil].
• Tenofovir is an acyclic nucleotide analogue of adenosine used in combination with other agents in the therapy of the human immunodeficiency virus (HIV) and as single agent in hepatitis B virus (HBV) infection. Tenofovir does not appear to be a significant cause of drug induced liver injury.
• Tenofovir-based topicalmicrobicides are investigational products that are being studied to prevent sexual transmission of HIV. They have also been studied to prevent herpes simplex virus type 2 (HSV-2) infection.
• Tenofovir, the HIV drug used in tenofovir-based microbicides, belongs to a class of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and from spreading to other cells.
• Truvada is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the following uses:
• To treat HIV in adults and children who weigh at least 37 lb (17 kg). Truvada for HIV treatment is always used in combination with other HIV medicines.

Synonyms

Tenofovir; 147127-20-6; (R)-9-(2-Phosphonomethoxypropyl)adenine; (R)-PMPA; tenofovir (anhydrous); Tenofovir anhydrous; GS-1275; anhydrous tenofovir; tenofovir (anh.); GS-1278; CHEBI:63625; [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid; ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid; W4HFE001U5; (R)-9-(Phosphonomethoxypropyl)adenine; (R)-9-(2-Phosphonylmethoxypropyl)adenine

Frequently Asked Questions

What are the CAS number and molecular formula of Tenofovir?

CAS 147127-20-6; molecular formula C9H14N5O4P; molecular weight — g/mol.

What other names is Tenofovir known by?

Tenofovir, 147127-20-6, (R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA, tenofovir (anhydrous), Tenofovir anhydrous.

Is Tenofovir classified as hazardous?

Hazard statements reported: H318.

What are the key physical properties of Tenofovir?

Boiling Point: 616; Melting Point: 279; Melting Point: 276 - 280 °C; Solubility: 13.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.