Tenoxicam

Description

Tenoxicam · CAS 59804-37-4 · C13H11N3O4S2. UNII Z1R9N0A399. Melting Point: 211; Solubility: 14.1; LogP: 1.9.

Identification

CAS Registry Number	59804-37-4
PubChem CID	54677971
Molecular formula	C13H11N3O4S2
IUPAC name	4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
UNII (FDA)	Z1R9N0A399

Computed Descriptors

Molecular Weight	337.4
XLogP3	1.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	337.01909819
Monoisotopic Mass	337.01909819
Topological Polar Surface Area	136
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	211
Solubility	14.1
LogP	1.9

Physical description & handling notes

• 169.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 170.4 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 172.58 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 169.37 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 175.02 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Regulatory Status

GHS notification summary	2.2% (1 / 46)

GHS Hazard Classification

GHS notification summary	2.2% (1 / 46)
Reported hazard statements	H301 (97.8%), H311 (89.1%), H331 (89.1%)

Documented Uses

• For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.
• Take with food. Food may minimize stomach upset caused by tenoxicam.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
• M01 - Antiinflammatory and antirheumatic products
• M01A - Antiinflammatory and antirheumatic products, non-steroids

Synonyms

tenoxicam; 59804-37-4; Mobiflex; Tilcotil; Tenoxicamum; Ro 12-0068; Ro 12-0068/000; DTXSID8045486; Ro-12-0068; NSC-758397; CHEBI:32192; Z1R9N0A399; 4-Hydroxy-2-methyl-N-2-pyridyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide; Ro-120068000; DTXCID6025486; RO-12-0068/000

Frequently Asked Questions

What are the CAS number and molecular formula of Tenoxicam?

CAS 59804-37-4; molecular formula C13H11N3O4S2; molecular weight — g/mol.

What other names is Tenoxicam known by?

tenoxicam, 59804-37-4, Mobiflex, Tilcotil, Tenoxicamum, Ro 12-0068.

Is Tenoxicam classified as hazardous?

2.2% of GHS notifications report no hazard classification (1 of 46).

What are the key physical properties of Tenoxicam?

Melting Point: 211; Solubility: 14.1; LogP: 1.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.