tolazoline

Description

tolazoline · CAS 59-98-3 · C10H12N2. UNII CHH9H12AQ3. Melting Point: 174; Melting Point: 174 °C; Solubility: 373.

Identification

CAS Registry Number	59-98-3
PubChem CID	5504
Molecular formula	C10H12N2
IUPAC name	2-benzyl-4,5-dihydro-1H-imidazole
UNII (FDA)	CHH9H12AQ3

Computed Descriptors

Molecular Weight	160.22
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	160.100048391
Monoisotopic Mass	160.100048391
Topological Polar Surface Area	24.4
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Melting Point	174
Melting Point	174 °C
Solubility	373
Solubility	1.36e+00 g/L
LogP	2.65
LogP	1.5
Dissociation Constants	10.3

Physical description & handling notes

• Solid
• 133.41 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 138.49 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 134.34 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).

GHS Hazard Classification

Reported hazard statements	H302, H312, H332 (44.1%), H315 (100%), H319 (100%), H335 (98.5%)

Documented Uses

• For the treatment of pulmonary artery anomalies
• Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Drugs used to cause dilation of the blood vessels.
• C04AB - Imidazoline derivatives
• M02 - Topical products for joint and muscular pain

Synonyms

tolazoline; 59-98-3; 2-Benzylimidazoline; 2-Benzyl-4,5-dihydro-1H-imidazole; Benzazoline; 2-Benzyl-2-imidazoline; 2-Benzyl-4,5-imidazoline; Tolazolina; Tolazine; Tolazolinum; 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole; 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-; CHH9H12AQ3; NSC-35110; Benzalolin; DTXSID3023683

Frequently Asked Questions

What are the CAS number and molecular formula of tolazoline?

CAS 59-98-3; molecular formula C10H12N2; molecular weight — g/mol.

What other names is tolazoline known by?

tolazoline, 59-98-3, 2-Benzylimidazoline, 2-Benzyl-4,5-dihydro-1H-imidazole, Benzazoline, 2-Benzyl-2-imidazoline.

Is tolazoline classified as hazardous?

Hazard statements reported: H302, H312, H332, H315, H319.

What are the key physical properties of tolazoline?

Melting Point: 174; Melting Point: 174 °C; Solubility: 373; Solubility: 1.36e+00 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.