Trandolapril

Description

Trandolapril · CAS 87679-37-6 · C24H34N2O5. UNII 1T0N3G9CRC. Melting Point: 119-123 °C; Melting Point: 125 °C; Melting Point: 119 - 123 °C.

Identification

CAS Registry Number	87679-37-6
PubChem CID	5484727
Molecular formula	C24H34N2O5
IUPAC name	(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
UNII (FDA)	1T0N3G9CRC

Computed Descriptors

Molecular Weight	430.5
XLogP3	2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	430.24677219
Monoisotopic Mass	430.24677219
Topological Polar Surface Area	95.9
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Melting Point	119-123 °C
Melting Point	125 °C
Melting Point	119 - 123 °C
Solubility	2.07e-02 g/L
LogP	3.5

Physical description & handling notes

• Solid
• Colorless, crystalline solid
• Soluble in chloroform, dichloromethane, methanol
• Stable under recommended storage conditions.
• pKa values of trandolapril[Table#8435]
• 203.5 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H361 (94.1%), H373 (96.1%), H360

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Preparation: H. Urback et al., European Patent Office patent 84164; eidem, United States of America patent 4933361 (1983, 1990 both to Hoechst).
• For the treatment of mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure (CHF), to improve survival following myocardial infarction (MI) in individuals who are hemodynamically stable and demonstrate symptoms of left ventricular systolic dysfunction or signs of CHF within a few days following acute MI, and to slow progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
• Trandolapril is an oral angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure. Trandolapril is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Angiotensin-Converting Enzyme Inhibitors; ACE Inhibitors

Synonyms

trandolapril; 87679-37-6; Mavik; Gopten; Odrik; Trandolaprilum [Latin]; RU 44570; RU-44570; Trandolaprilum; Udrik; DTXSID2023692; 1T0N3G9CRC; RU44570; NSC-758939; CHEBI:9649; DTXCID003692

Frequently Asked Questions

What are the CAS number and molecular formula of Trandolapril?

CAS 87679-37-6; molecular formula C24H34N2O5; molecular weight — g/mol.

What other names is Trandolapril known by?

trandolapril, 87679-37-6, Mavik, Gopten, Odrik, Trandolaprilum [Latin].

Is Trandolapril classified as hazardous?

Hazard statements reported: H361, H373, H360.

What are the key physical properties of Trandolapril?

Melting Point: 119-123 °C; Melting Point: 125 °C; Melting Point: 119 - 123 °C; Solubility: 2.07e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.