曲唑酮

Description

Trazodone · CAS 19794-93-5 · C19H22ClN5O. UNII YBK48BXK30. Boiling Point: 528.5; Melting Point: 231-234; Melting Point: 86 - 87 °C.

Identification

CAS Registry Number	19794-93-5
PubChem CID	5533
Molecular formula	C19H22ClN5O
IUPAC name	2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
UNII (FDA)	YBK48BXK30

Computed Descriptors

Molecular Weight	371.9
XLogP3	2.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	371.1512880
Monoisotopic Mass	371.1512880
Topological Polar Surface Area	42.4
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Boiling Point	528.5
Melting Point	231-234
Melting Point	86 - 87 °C
Solubility	2.90e-01 g/L
LogP	2.68
LogP	2.9
LogP	2.92
Ionization Efficiency	4.22
Ionization Efficiency	2.09
Ionization Efficiency	MeCN (90%)

Physical description & handling notes

• Solid
• Crystals
• 86-87 °C, also reported as mp 96 °C
• White, odorless plates from ethanol, MP: 223 °C. Sparingly soluble in water, ethanol, methanol, chloroform. Practically insoluble in common organic solvents. UV max (water): 211, 246, 274, 312 nm (epsilon = 50100, 11730, 3840, 3840) /Trazodone hydrochloride/
• Stable under recommended storage conditions. /Trazadone hydrochloride/
• When heated to decomposition it emits toxic fumes of /chlorides, hydrogen chloride and nitrogen oxides/.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H351

Documented Uses

• Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Serotonin Uptake Inhibitors
• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• Consumption (g per capita) in the USA (2002): 0.0741
• For the treatment of depression.
• Semicarbazide and 2-chloropyridine are condensed with loss of water and ammonia to form 1,2,4-triazolo[4,3-alpha]pyridin3(2H)-one, with on treatment with 1-(3-chlorophenyl)4,3-chlorophenyl)piperazine and sodamide, yields trazodone.

Synonyms

trazodone; 19794-93-5; Trazodon; Beneficat; Trazalon; Trazodil; Trazodona; Trazonil; Trittico; Desirel; Sideril; Trazodonum; Molipaxin; Trazodonum [Latin]; Desyrel Dividose; 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-

Frequently Asked Questions

What are the CAS number and molecular formula of Trazodone?

CAS 19794-93-5; molecular formula C19H22ClN5O; molecular weight — g/mol.

What other names is Trazodone known by?

trazodone, 19794-93-5, Trazodon, Beneficat, Trazalon, Trazodil.

Is Trazodone classified as hazardous?

Hazard statements reported: H302, H351.

What are the key physical properties of Trazodone?

Boiling Point: 528.5; Melting Point: 231-234; Melting Point: 86 - 87 °C; Solubility: 2.90e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.