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Description

Triamterene · CAS 396-01-0 · C12H11N7. UNII WS821Z52LQ. Melting Point: 601 °F (NTP, 1992); Melting Point: 316; Melting Point: 316 °C.

Identification

CAS Registry Number	396-01-0
PubChem CID	5546
Molecular formula	C12H11N7
IUPAC name	6-phenylpteridine-2,4,7-triamine
UNII (FDA)	WS821Z52LQ

Computed Descriptors

Molecular Weight	253.26
XLogP3	1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	253.10759338
Monoisotopic Mass	253.10759338
Topological Polar Surface Area	130
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	601 °F (NTP, 1992)
Melting Point	316
Melting Point	316 °C
LogP	0.98
LogP	log Kow = 0.98
LogP	1.24
Dissociation Constants	pKa = 6.2

Physical description & handling notes

• Triamterene appears as odorless yellow powder or crystalline solid. Melting point 316 °C. Almost tasteless at first and with a slightly bitter aftertaste. Acidified solutions give a blue fluorescence. Used as a diuretic drug.
• Solid
• Yellow plates from butanol
• Crystals from dimethylformamide
• Yellow crystalline powder
• Odorless

GHS Hazard Classification

Reported hazard statements	H302 (91.7%), H315 (93.8%), H319 (93.8%), H335 (91.7%)

Documented Uses

• Diuretics; Epithelial Sodium Channel Blockers
• Use (kg; approx.) in Germany (2009): >7500
• Consumption (g per capita; approx.) in Germany (2009): 0.0916
• Consumption (g per capita) in the USA (2002): 0.135
• 5-Nitroso-2,4,6-triaminopyrimidine is refluxed with phenylacetonitrile in the presence of sodium methoxide.
• By condensation of 2,4,6-triamino-5-nitrosopyrimidine with benzyl cyanide.

Synonyms

triamterene; 396-01-0; 6-phenylpteridine-2,4,7-triamine; 2,4,7-Triamino-6-phenylpteridine; Dyrenium; Dytac; Pterophene; Triamteren; Diurene; Noridil; Pterofen; Taturil; Teridin; Triteren; Ademine; Jatropur

Frequently Asked Questions

What are the CAS number and molecular formula of Triamterene?

CAS 396-01-0; molecular formula C12H11N7; molecular weight — g/mol.

What other names is Triamterene known by?

triamterene, 396-01-0, 6-phenylpteridine-2,4,7-triamine, 2,4,7-Triamino-6-phenylpteridine, Dyrenium, Dytac.

Is Triamterene classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

What are the key physical properties of Triamterene?

Melting Point: 601 °F (NTP, 1992); Melting Point: 316; Melting Point: 316 °C; LogP: 0.98.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.