Triclabendazole

Description

Triclabendazole · CAS 68786-66-3 · C14H9Cl3N2OS. UNII 4784C8E03O. Boiling Point: 496; Melting Point: 189-191; LogP: 3.48.

Identification

CAS Registry Number	68786-66-3
PubChem CID	50248
Molecular formula	C14H9Cl3N2OS
IUPAC name	6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole
UNII (FDA)	4784C8E03O

Computed Descriptors

Molecular Weight	359.7
XLogP3	5.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	357.950117
Monoisotopic Mass	357.950117
Topological Polar Surface Area	63.2
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Boiling Point	496
Melting Point	189-191
LogP	3.48

Physical description & handling notes

• 0.5 [ug/mL] (The mean of the results at pH 7.4)
• 179.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 179.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with Waters Major Mix]
• 176.99 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Triclabendazole and its metabolites are active against both the immature and mature worms of _Fasciola hepatica_ and _Fasciola gigantica_ helminths. **Effect on QT interval** This drug may prolong the cardiac QT interval. Monitor ECG in patients with a history of QT prolongation or who are taking medications known to prolong the QT interval.

Regulatory Status

Regulatory & Food Contact	ANTHELMINTHIC_AGENT: Veterinary Drug CGA89317 0–3mg/kg bw TRS 969/JECFA 75 FAS 31-JECFA 40/63 (1992) FASIMEC®
GHS notification summary	51.2% (41 / 80)

GHS Hazard Classification

GHS notification summary	51.2% (41 / 80)
Reported hazard statements	H373 (43.8%)

Documented Uses

• Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
• This drug is indicated for the treatment of fascioliasis in patients aged 6 years old and above.
• Triclabendazole is an oral anthelmintic used in the treatment of chronic fascioliasis also known as liver flukes. Triclabendazole therapy is generally well tolerated but can be accompanied by abdominal pain, nausea and mild liver test abnormalities, which are probably due to the expulsion of dead or dying flukes rather than hepatic injury due to the therapy.
• Breastfeeding; Lactation; Milk, Human; Anti-Infective Agents; Antiparasitic Agents; Antiplatyhelmintic Agents
• Antischistosomals and other antitrematode medicines
• Oral - Solid - tablet: 250 mg (scored)

Synonyms

Triclabendazole; 68786-66-3; Fasinex; Triclabendazol; Egaten; Triclabendazolum; DTXSID7043952; 5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole; NVP-EGA230; EGA230B; 1H-Benzimidazole, 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-; NSC-759250; 4784C8E03O; DTXCID5023952; 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole; Egaten tm

Frequently Asked Questions

What are the CAS number and molecular formula of Triclabendazole?

CAS 68786-66-3; molecular formula C14H9Cl3N2OS; molecular weight — g/mol.

What other names is Triclabendazole known by?

Triclabendazole, 68786-66-3, Fasinex, Triclabendazol, Egaten, Triclabendazolum.

What is the regulatory status of Triclabendazole?

Documented regulatory listings: ANTHELMINTHIC_AGENT: Veterinary Drug; CGA89317; 0–3mg/kg bw.

Is Triclabendazole classified as hazardous?

51.2% of GHS notifications report no hazard classification (41 of 80).

What are the key physical properties of Triclabendazole?

Boiling Point: 496; Melting Point: 189-191; LogP: 3.48.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.