三氯生

Description

Triclosan · CAS 3380-34-5 · C12H7Cl3O2. UNII 4NM5039Y5X. Boiling Point: 120; Boiling Point: 280 to 290 °C (decomposes); Melting Point: 55-57 °C.

Identification

CAS Registry Number	3380-34-5
PubChem CID	5564
Molecular formula	C12H7Cl3O2
IUPAC name	5-chloro-2-(2,4-dichlorophenoxy)phenol
UNII (FDA)	4NM5039Y5X

Computed Descriptors

Molecular Weight	289.5
XLogP3	5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	287.951163
Monoisotopic Mass	287.951163
Topological Polar Surface Area	29.5
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Boiling Point	120
Boiling Point	280 to 290 °C (decomposes)
Melting Point	55-57 °C
Melting Point	54-57.3 °C
Solubility	In water, 10 mg/L at 20 °C
Vapor Pressure	0.0000046 [mmHg]
LogP	log Kow = 4.76
LogP	4.53
Dissociation Constants	7.9
Dissociation Constants	pKa = 7.9

Physical description & handling notes

• White to off-white crystalline powder; [HSDB]
• White to off-white crystalline powder
• Slight, faintly aromatic odor
• Slightly soluble in water
• Readily soluble in alkaline solutions and many organic solvents; soluble in methanol, alcohol, acetone
• Readily soluble in organic solvents

Regulatory Status

Regulatory & Food Contact	CIR / INCI: Cosmetic ingredients (Triclosan) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Preservative

GHS Hazard Classification

Reported hazard statements	H315, H319, H400, H410, H331, H335

Documented Uses

• A halogenated phenol used in cosmetics and toilet soaps as an antiseptic and disinfectant; [Marks, p. 235]
• Using Disinfectants or Biocides [Category: Clean]
• It is highly active against staphylococci and is used as an active agent in deodorants and antiseptic soaps.
• ... antimicrobial liquid and bar soaps, antiseptics, antimicrobial detergents, skin care and oral care products, for the antimicrobial treatment of plastics and textile products.
• For more Uses (Complete) data for Triclosan (9 total), please visit the HSDB record page.
• Triclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers. It is also used in health care settings in surgical scrubs and personnel hand washes.

Synonyms

triclosan; 3380-34-5; 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL; Cloxifenolum; 2,4,4'-Trichloro-2'-hydroxydiphenyl ether; Triclosanum; Irgasan DP300; Stri-Dex Cleansing Bar; Stri-Dex Face Wash; CH 3565; Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-; Lexol 300; 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol; CH-3565; DTXSID5032498; Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-

Frequently Asked Questions

What are the CAS number and molecular formula of Triclosan?

CAS 3380-34-5; molecular formula C12H7Cl3O2; molecular weight — g/mol.

What other names is Triclosan known by?

triclosan, 3380-34-5, 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL, Cloxifenolum, 2,4,4'-Trichloro-2'-hydroxydiphenyl ether, Triclosanum.

What is the regulatory status of Triclosan?

Documented regulatory listings: CIR / INCI: Cosmetic ingredients (Triclosan) -> CIR (Cosmetic Ingredient Review); CIR / INCI: Preservative.

Is Triclosan classified as hazardous?

Hazard statements reported: H315, H319, H400, H410, H331.

What are the key physical properties of Triclosan?

Boiling Point: 120; Boiling Point: 280 to 290 °C (decomposes); Melting Point: 55-57 °C; Melting Point: 54-57.3 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.