曲格列酮

Description

Troglitazone · CAS 97322-87-7 · C24H27NO5S. UNII I66ZZ0ZN0E. Melting Point: 184-186 °C; LogP: 3.6; LogP: 2.7.

Identification

CAS Registry Number	97322-87-7
PubChem CID	5591
Molecular formula	C24H27NO5S
IUPAC name	5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
UNII (FDA)	I66ZZ0ZN0E

Computed Descriptors

Molecular Weight	441.5
XLogP3	5.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	441.16099414
Monoisotopic Mass	441.16099414
Topological Polar Surface Area	110
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Melting Point	184-186 °C
LogP	3.6
LogP	2.7

Physical description & handling notes

• 193.9 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID8023719]

Documented Uses

• For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
• Troglitazone was the first thiazolidinedione approved for use in the United States and was licensed for use in type 2 diabetes in 1997, but withdrawn 3 years later because of the frequency of liver injury including acute liver failure associated with its use.
• Substances which lower blood glucose levels.
• A - Alimentary tract and metabolism
• A10B - Blood glucose lowering drugs, excl. insulins
• QA - Alimentary tract and metabolism

Synonyms

troglitazone; 97322-87-7; Rezulin; Romglizone; Prelay; CS-045; Romozin; Noscal; troglitazona; troglitazonum; CI-991; DTXSID8023719; GR92132X; GR-92132X; 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione; CHEBI:9753

Frequently Asked Questions

What are the CAS number and molecular formula of Troglitazone?

CAS 97322-87-7; molecular formula C24H27NO5S; molecular weight — g/mol.

What other names is Troglitazone known by?

troglitazone, 97322-87-7, Rezulin, Romglizone, Prelay, CS-045.

What are the key physical properties of Troglitazone?

Melting Point: 184-186 °C; LogP: 3.6; LogP: 2.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.