乌拉地尔

Description

urapidil · CAS 34661-75-1 · C20H29N5O3. UNII A78GF17HJS. LogP: 1.6.

Identification

CAS Registry Number	34661-75-1
PubChem CID	5639
Molecular formula	C20H29N5O3
IUPAC name	6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
UNII (FDA)	A78GF17HJS

Computed Descriptors

Molecular Weight	387.5
XLogP3	1.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	387.22703980
Monoisotopic Mass	387.22703980
Topological Polar Surface Area	68.4
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

LogP	1.6

Physical description & handling notes

• 178.64 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 195.14 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 193.26 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 190.92 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	0.7% (1 / 148)

GHS Hazard Classification

GHS notification summary	0.7% (1 / 148)
Reported hazard statements	H302 (99.3%), H315 (26.4%), H319 (26.4%), H335 (26.4%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Drugs used to cause dilation of the blood vessels.
• Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
• Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.

Synonyms

urapidil; 34661-75-1; Ebrantil; Urapidilum; DTXSID9021425; A78GF17HJS; NSC-310405; 6-(3-(4-(o-Methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil; 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione; DTXCID501425; 6-((3-(4-(2-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione; 6-[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propylamino]-1,3-dimethyluracil; RefChem:933840; C02CA06; 6-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-1,3-dimethyluracil; 252-130-4

Frequently Asked Questions

What are the CAS number and molecular formula of urapidil?

CAS 34661-75-1; molecular formula C20H29N5O3; molecular weight — g/mol.

What other names is urapidil known by?

urapidil, 34661-75-1, Ebrantil, Urapidilum, DTXSID9021425, A78GF17HJS.

Is urapidil classified as hazardous?

0.7% of GHS notifications report no hazard classification (1 of 148).

What are the key physical properties of urapidil?

LogP: 1.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.