Vancomycin

Description

Vancomycin is identified by CAS 1404-90-6, molecular formula C66H75Cl2N9O24 and molecular weight 1447.43 g/mol. UNII 6Q205EH1VU; ChEBI 28001; InChIKey MYPYJXKWCTUITO-LYRMYLQWSA-N. Solubility: 2.25e-01 g/L; LogP: -3.1; Dissociation Constants: 2.66.

Identification

CAS Registry Number	1404-90-6
PubChem CID	14969
Molecular formula	C66H75Cl2N9O24
Molecular weight	1447.43 g/mol
InChIKey	MYPYJXKWCTUITO-LYRMYLQWSA-N
UNII (FDA)	6Q205EH1VU
ChEBI ID	CHEBI:28001
ATC code (WHO)	A07AA09

Computed Descriptors

Molecular Weight	1449.2
XLogP3	-2.6
Hydrogen Bond Donor Count	19
Hydrogen Bond Acceptor Count	26
Rotatable Bond Count	13
Exact Mass	1447.4301997
Monoisotopic Mass	1447.4301997
Topological Polar Surface Area	530
Heavy Atom Count	101
Formal Charge	0

Physical & Chemical Properties

Solubility	2.25e-01 g/L
LogP	-3.1
Dissociation Constants	2.66

Physical description & handling notes

• Tan to brown solid; [HSDB]
• Solid
• White solid; solubility in water: greater than 100 mg/mL; moderately soluble in methanol; insoluble in higher alcohols, acetone, ether; UV max absorption (water): 282 nm (e = 40, 1%, 1 cm) /Vancomycin hydrochloride/
• Solutions are stable for two weeks at room temp or longer if refrigerated. /Hydrochloride/
• When heated to decomposition, it emits toxic fumes of /nitric oxide/ and /chlorine/.
• pka1 = 2.6; pKa2 = 7.2; pKa3 = 8.6; pKa4 = 9.6; pKa5 = 10.5; pKa6 = 11.7

GHS Hazard Classification

Reported hazard statements	H334 (95.8%)

Documented Uses

• Medicine (antibiotic) /Vancomycin hydrochloride/
• THERAPEUTIC CATEGORY: Antibacterial
• Use (kg) in Switzerland (2009): >100
• Use (kg; approx.) in Germany (2009): >1000
• Use (kg; exact) in Germany (2009): 2351
• Consumption (g per capita) in Switzerland (2009): 0.013

Synonyms

VANCOMYCIN; 1404-90-6; Vancomicina; Vancomycine; Vancomycinum; 6Q205EH1VU; DTXSID0042664; CHEBI:28001; Vancocin HCL; Vancomycin Lilly; Sulfate, Vancomycin; RefChem:6345; A07AA09; J01XA01; S01AA28; DTXCID401031367

Frequently Asked Questions

What are the CAS number and molecular formula of Vancomycin?

CAS 1404-90-6; molecular formula C66H75Cl2N9O24; molecular weight 1447.43 g/mol.

What other names is Vancomycin known by?

VANCOMYCIN, 1404-90-6, Vancomicina, Vancomycine, Vancomycinum, 6Q205EH1VU.

Is Vancomycin classified as hazardous?

Hazard statements reported: H334.

What are the key physical properties of Vancomycin?

Solubility: 2.25e-01 g/L; LogP: -3.1; Dissociation Constants: 2.66.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.