藜芦胺

Description

veratramine · CAS 60-70-8 · C27H39NO2. UNII RK363YG315. Melting Point: MP: 209.5-210.5 °C /HYDRATE/.

Identification

CAS Registry Number	60-70-8
PubChem CID	6070
Molecular formula	C27H39NO2
IUPAC name	(2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol
UNII (FDA)	RK363YG315

Computed Descriptors

Molecular Weight	409.6
XLogP3	4.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	409.298079487
Monoisotopic Mass	409.298079487
Topological Polar Surface Area	52.5
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Melting Point	MP: 209.5-210.5 °C /HYDRATE/

Physical description & handling notes

• Solid; [Merck Index]
• CRYSTALS
• NEEDLES
• SLIGHTLY SOL IN WATER; SOL IN METHANOL, ALC
• SOL IN BENZENE, CHLOROFORM, DIL ACID; INSOL IN DIL ALKALI
• SPECIFIC OPTICAL ROTATION: -71.8 DEG @ 25 °C/D (WATER 1.21%), -70 DEG @ 25 °C/D (METHANOL 1.56%); MAX ABSORPTION: 268 NM

GHS Hazard Classification

Reported hazard statements	H302 (90.5%), H312 (90.5%), H332 (90.5%)

Documented Uses

• Secondary base in plants of the veratrum genus; [Merck Index]
• Veratramine is a hypotensive alkaloid isolated from the rhizomes of Veratrum.
• 3 OR 4. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB). /VERATRUM VIRIDE ALKALOIDS/
• L-ETHOMOXANE HYDROCHLORIDE CAUSED 1/30TH & BETWEEN 1/10 & 1/20TH OF THE NEGATIVE CHRONOTROPIC EFFECT INDUCED BY VERATRAMINE ON THE DOG HEART-LUNG PREPN & ON THE ISOLATED GUINEA PIG ATRIUM, RESPECTIVELY.

Synonyms

VERATRAMINE; 60-70-8; (3beta,23beta)-14,15,16,17-Tetradehydroveratraman-3,23-diol; RK363YG315; NSC-17821; NSC-23880; CHEBI:9951; DTXSID40871534; (3beta,23R)-14,15,16,17-tetradehydroveratraman-3,23-diol; Veratraman-3,23-diol, 14,15,16,17-tetradehydro-, (3beta,23beta)-; RefChem:193959; DTXCID501474790; (3 beta,23 beta)-14,15,16,17-tetradehydroveratraman-3,23-diol; NSC 17821; NSC 23880; Vreaframine

Frequently Asked Questions

What are the CAS number and molecular formula of veratramine?

CAS 60-70-8; molecular formula C27H39NO2; molecular weight — g/mol.

What other names is veratramine known by?

VERATRAMINE, 60-70-8, (3beta,23beta)-14,15,16,17-Tetradehydroveratraman-3,23-diol, RK363YG315, NSC-17821, NSC-23880.

Is veratramine classified as hazardous?

Hazard statements reported: H302, H312, H332.

What are the key physical properties of veratramine?

Melting Point: MP: 209.5-210.5 °C /HYDRATE/.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.