Description
Vinblastine sulfate · CAS 143-67-9 · C46H58N4O9. UNII 5V9KLZ54CY. Melting Point: 267; Melting Point: 211-216 °C; LogP: 3.7.
Identification
| CAS Registry Number | 143-67-9 |
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| PubChem CID | 13342 |
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| Molecular formula | C46H58N4O9 |
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| UNII (FDA) | 5V9KLZ54CY |
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Computed Descriptors
| Molecular Weight | 811.0 |
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| XLogP3 | 3.7 |
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| Hydrogen Bond Donor Count | 3 |
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| Hydrogen Bond Acceptor Count | 12 |
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| Rotatable Bond Count | 10 |
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| Exact Mass | 810.42037944 |
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| Monoisotopic Mass | 810.42037944 |
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| Topological Polar Surface Area | 154 |
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| Heavy Atom Count | 59 |
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| Formal Charge | 0 |
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Physical & Chemical Properties
| Melting Point | 267 |
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| Melting Point | 211-216 °C |
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| LogP | 3.7 |
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| LogP | log Kow = 3.70 |
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| LogP | 3.72 |
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| Dissociation Constants | pKa1 = 5.4; pKa2 = 7.4 |
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Physical description & handling notes
- Solvated needles from methanol
- Negligible
- ODORLESS & HYGROSCOPIC; WHITE TO SLIGHTLY YELLOW, AMORPHOUS OR CRYSTALLINE POWDER; FREELY SOL IN WATER /VINBLASTINE SULFATE/
- Practically insoluble in water, petroleum ether; soluble in alcohols, acetone, ethyl acetate, chloroform
- SOLN MAY BE STORED IN REFRIGERATOR FOR PERIODS OF 30 DAYS WITHOUT SIGNIFICANT LOSS OF POTENCY /VINBLASTINE SULFATE/
- Crystallizes as hydrate, mp 284-285 °C. Specific optical rotation = - 28 deg at 26 °C/D ( c = 1.01 in methanol); UV max (Methanol): 212, 262, 282, 292 nm (log epsilon = 4.75, 4.28, 4.22, 4,18). Very slightly soluble in ethanol. Practically insoluble in ether. One part is soluble in 10 parts of water, 50 parts of chloroform /Sulfate/
Documented Uses
- For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
- ... in the treatment of Hodgkins disease /Vinblastine sulfate USP/
- ... Isolated from periwinkle, Vinca rosea Linn, Apocynaceae.
- BY EXTRACTING LEAVES, BARK, OR STEMS OF VINCA ROSEA ... ISOLATING ALKALOID ... BY PRECIPITATION & SOLVENT TECHNIQUES, & PURIFYING BY CHROMATOGRAPHY ... CONVERSION TO (1:1) SULFATE ... BY DISSOLVING ALKALOID IN EQUIMOLAR QUANTITY OF DILUTE SULFURIC ACID & ... EVAPORATING TO DRYNESS OR PRECIPITATING WITH SUITABLE ORG SOLVENT. /VINBLASTINE SULFATE/
- Vinblastine and vincristine occur in Catharanthus roseus (L). The plant contains only very small amounts of vinblastine and vincristine, and their isolation is correspondingly difficult. First the alkaloids present are separated by extraction into alkaloid tartrate soluble in benzene and alkaloid tartrates insoluble in benzene. Vinblastine and vincristine belong to the first group. They then are separated by chromatography on aluminum oxide deactivated with acetic acid.
- VINBLASTINE IS CLASS II IMMUNOSUPPRESSIVE DRUG, BUT IT HAS NOT BEEN EXPLOITED FOR THIS PURPOSE. /VINBLASTINE SULFATE/
Synonyms
vinblastine; 865-21-4; Vinblastin; Vincaleucoblastin; Vinblastina; Vincoblastine; Vincaleukoblastine; Nincaluicolflastine; Vinblastinum; Vincaleucoblastine; NCI-C04842; 5V9KLZ54CY; NSC 47842; NDC 0002-1452-01; NSC-47842; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
Frequently Asked Questions
What are the CAS number and molecular formula of Vinblastine sulfate?
CAS 143-67-9; molecular formula C46H58N4O9; molecular weight — g/mol.
What other names is Vinblastine sulfate known by?
vinblastine, 865-21-4, Vinblastin, Vincaleucoblastin, Vinblastina, Vincoblastine.
What are the key physical properties of Vinblastine sulfate?
Melting Point: 267; Melting Point: 211-216 °C; LogP: 3.7; LogP: log Kow = 3.70.
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.
