vindesine sulfate

Description

vindesine sulfate · CAS 59917-39-4 · C43H55N5O7. UNII RSA8KO39WH. Melting Point: 230-232 °C; Melting Point: 230 - 232 °C; Solubility: 7.00e-02 g/L.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Solid
• Crystal from ethanol-methanol
• Vindesine sulfate is most stable at pH 1.9. It may precipitate in a soln with a pH >6. ... Vindesine sulfate 20 ug/ml in dextrose 5% in water, Ringer's injection, lactate, or sodium chloride 0.9% underwent no degradation after 4 wk when frozen at -20 °C. /Vindesine sulfate/
• Optical rotation: +39.4 deg (c = 1.0 in methanol)

Documented Uses

• Vindesine is used in chemotherapy to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer (L1022).
• For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis
• Vindesine is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine. /Included in US product labeling/
• Vindesine is indicated for the treatment of non-oat cell lung cancer. /Included in US product labeling/
• Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of vindesine in children.
• It is important to strictly adhere to the recommended dosage schedule. The use of small amounts of vindesine daily for long periods for the treatment of children with acute lymphocytic leukemia is not advised, even though the resulting weekly dosage may be similar to the recommended dosage. Little or no therapeutic benefit has been demonstrated when such regimens are used, and the incidence of adverse reactions is increased

Synonyms

vindesine; 53643-48-4; Desacetylvinblastine amide; Vindesinum; Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-; DTXSID6023739; Vindesin; CHEBI:36373; 3-(aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine; Compound 112531; vindesin sulfate; vindesin sulphate; Lilly CT-3231; RefChem:901872; Deacetylvinblastine Carboxamide; DTXCID203739

Frequently Asked Questions

What are the CAS number and molecular formula of vindesine sulfate?

CAS 59917-39-4; molecular formula C43H55N5O7; molecular weight — g/mol.

What other names is vindesine sulfate known by?

vindesine, 53643-48-4, Desacetylvinblastine amide, Vindesinum, Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)-, DTXSID6023739.

What are the key physical properties of vindesine sulfate?

Melting Point: 230-232 °C; Melting Point: 230 - 232 °C; Solubility: 7.00e-02 g/L; LogP: 2.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.