Voriconazole

Description

Voriconazole · CAS 137234-62-9 · C16H14F3N5O. UNII JFU09I87TR. Melting Point: 134; Melting Point: 127 - 130 °C; Solubility: 9.78e-02 g/L.

Identification

CAS Registry Number	137234-62-9
PubChem CID	71616
Molecular formula	C16H14F3N5O
IUPAC name	(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
UNII (FDA)	JFU09I87TR

Computed Descriptors

Molecular Weight	349.31
XLogP3	1.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	349.11504457
Monoisotopic Mass	349.11504457
Topological Polar Surface Area	76.7
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	134
Melting Point	127 - 130 °C
Solubility	9.78e-02 g/L
LogP	1.7

Physical description & handling notes

• Solid
• Low
• Voriconazole is a fungistatic triazole antifungal used to treat infections by inhibiting fungal growth. It is known to cause hepatotoxic and photosensitivity reactions in some patients.

GHS Hazard Classification

Reported hazard statements	H301 (99.2%), H351 (93.2%), H360 (32.2%), H361 (66.9%), H373 (97.5%), H400 (23.7%), H410 (23.7%), H412 (96.6%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
• Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. Voriconazole therapy is associated with transient, asymptomatic serum aminotransferase elevations and is a known cause of clinically apparent acute drug induced liver injury.
• Breast Feeding; Lactation; Milk, Human; Antifungal Agents
• (1) Parenteral - General injections - IV: 200 mg in vial powder for injection; (2) Oral - Liquid: 40 mg per mL powder for oral liquid; (3) Oral - Solid: 50 mg tablet; 200 mg tablet

Synonyms

Voriconazole; 137234-62-9; Vfend; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; UK-109496; Voriconazol; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol; Voriconazolum; UK-109,496; UK 109496; JFU09I87TR; NSC-759888; DTXSID5046485; CHEBI:10023; DTXCID3026485; UK109496

Frequently Asked Questions

What are the CAS number and molecular formula of Voriconazole?

CAS 137234-62-9; molecular formula C16H14F3N5O; molecular weight — g/mol.

What other names is Voriconazole known by?

Voriconazole, 137234-62-9, Vfend, (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496, Voriconazol.

Is Voriconazole classified as hazardous?

Hazard statements reported: H301, H351, H360, H361, H373.

What are the key physical properties of Voriconazole?

Melting Point: 134; Melting Point: 127 - 130 °C; Solubility: 9.78e-02 g/L; LogP: 1.7.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.