yohimbine

Description

yohimbine · CAS 146-48-5 · C21H26N2O3. UNII 2Y49VWD90Q. Melting Point: 241; Melting Point: 241 °C; Solubility: 3.48e-01 g/L.

Identification

CAS Registry Number	146-48-5
PubChem CID	8969
Molecular formula	C21H26N2O3
IUPAC name	methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
UNII (FDA)	2Y49VWD90Q

Computed Descriptors

Molecular Weight	354.4
XLogP3	2.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	354.19434270
Monoisotopic Mass	354.19434270
Topological Polar Surface Area	65.6
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	241
Melting Point	241 °C
Solubility	3.48e-01 g/L
LogP	2.73
LogP	2.01

Physical description & handling notes

• Solid
• 189.51 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 180.83 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 171.67 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 184.88 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 186.5 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H301 (100%), H311 (96.3%), H331 (96.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Indicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins.
• Yohimbine is an indole alkaloid derived from the bark of the Central African yohimbe tree (Pausinystalia yohimbe) that is widely used as therapy for erectile dysfunction. Yohimbine use has been associated with occasional severe adverse events, but has not been linked to serum enzyme elevations or clinically apparent acute liver injury.
• Yohimbine (Class: Hallucinogens, Added Date: 10-1998)
• Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.

Synonyms

Yohimbine; 146-48-5; Yohimbin; Quebrachine; Corynine; Quebrachin; APHRODINE; Yohimbic acid methyl ester; (+)-Yohimbine; Yohimbinum; DTXSID9040130; 17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester; 2Y49VWD90Q; methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate; (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-

Frequently Asked Questions

What are the CAS number and molecular formula of yohimbine?

CAS 146-48-5; molecular formula C21H26N2O3; molecular weight — g/mol.

What other names is yohimbine known by?

Yohimbine, 146-48-5, Yohimbin, Quebrachine, Corynine, Quebrachin.

Is yohimbine classified as hazardous?

Hazard statements reported: H301, H311, H331.

What are the key physical properties of yohimbine?

Melting Point: 241; Melting Point: 241 °C; Solubility: 3.48e-01 g/L; LogP: 2.73.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.