甲氨蝶呤二钠盐

Description

Methotrexate disodium salt is identified by CAS 7413-34-5, molecular formula C20H20N8Na2O5 and molecular weight 498.14 g/mol. UNII 3IG1E710ZN; ChEBI 50679; InChIKey DASQOOZCTWOQPA-GXKRWWSZSA-L.

Identification

CAS Registry Number	7413-34-5
PubChem CID	11329481
Molecular formula	C20H20N8Na2O5
Molecular weight	498.14 g/mol
IUPAC name	disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
InChIKey	DASQOOZCTWOQPA-GXKRWWSZSA-L
UNII (FDA)	3IG1E710ZN
ChEBI ID	CHEBI:50679

Computed Descriptors

Molecular Weight	498.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	7
Exact Mass	498.13520433
Monoisotopic Mass	498.13520433
Topological Polar Surface Area	216
Heavy Atom Count	35
Formal Charge	0
Complexity	693

GHS Hazard Classification

Reported hazard statements	H301 (100%), H311 (98.1%), H315 (100%), H319 (100%), H331 (98.1%), H335 (98.1%), H340 (98.1%), H360 (100%)

Documented Uses

• Breast Feeding; Lactation; Milk, Human; Abortifacient Agents, Nonsteroidal; Antimetabolites, Antineoplastic; Antirheumatic Agents; Folic Acid Antagonists; Immunosuppressive Agents
• Methotrexate sodium is approved to be used alone or with other drugs to treat:
• • Acute lymphoblastic leukemia (ALL), including ALL that has spread to the central nervous system, or to prevent it from spreading there. It is used in adults and children.
• • Gestational trophoblastic disease.
• • Head and neck cancer (certain types).
• • Mycosis fungoides (a type of cutaneous T-cell lymphoma) that is advanced. It is used in adults.

Synonyms

Methotrexate disodium salt; 7413-34-5; METHOTREXATE SODIUM; Sodium methotrexate; Disodium methotrexate; Abitrexate; Trexall; Methotrexate Lpf; Folex Pfs; Mexate-Aq Preserved; Mexate-Aq; Methotrexate sodium salt; Methotrexate, Sodium Salt; Methotrexate (as disodium); ADX-2191 SODIUM; Methotrexate Preservative Free

Frequently Asked Questions

What are the CAS number and molecular formula of Methotrexate disodium salt?

CAS 7413-34-5; molecular formula C20H20N8Na2O5; molecular weight 498.14 g/mol.

What other names is Methotrexate disodium salt known by?

Methotrexate disodium salt, 7413-34-5, METHOTREXATE SODIUM, Sodium methotrexate, Disodium methotrexate, Abitrexate.

Is Methotrexate disodium salt classified as hazardous?

Hazard statements reported: H301, H311, H315, H319, H331.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.