2,4,6-三甲基吡啶

Description

2,4,6-Collidine is identified by CAS 108-75-8, molecular formula C8H11N and molecular weight 121.09 g/mol. UNII 7IE4BK5J5V; ChEBI 189131; InChIKey BWZVCCNYKMEVEX-UHFFFAOYSA-N. Boiling Point: 170.4 °C; Melting Point: -44.5 °C; Flash Point: 58 °C.

Identification

CAS Registry Number	108-75-8
PubChem CID	7953
Molecular formula	C8H11N
Molecular weight	121.09 g/mol
IUPAC name	2,4,6-trimethylpyridine
InChIKey	BWZVCCNYKMEVEX-UHFFFAOYSA-N
UNII (FDA)	7IE4BK5J5V
ChEBI ID	CHEBI:189131

Computed Descriptors

Molecular Weight	121.18
XLogP3	1.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	121.089149355
Monoisotopic Mass	121.089149355
Topological Polar Surface Area	12.9
Heavy Atom Count	9
Formal Charge	0

Physical & Chemical Properties

Boiling Point	170.4 °C
Melting Point	-44.5 °C
Flash Point	58 °C
Flash Point	136 °F
Density	0.913 @ 20 °C/20 °C
Vapor Pressure	1.99 [mmHg]
Vapor Pressure	1.99 mm Hg @ 25 °C
LogP	log Kow = 1.88
LogP	2.01
Ionization Efficiency	3.93

Physical description & handling notes

• Collidine appears as a clear colorless liquid. Less dense than water and insoluble in water. Hence floats on water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make other chemicals.
• Colorless liquid with an aromatic odor; [HSDB] Colorless liquid with an unpleasant odor; [Alfa Aesar MSDS]
• Colorless liquid
• Aromatic odor
• Sol in methanol, ethanol, chloroform, benzene, toluene, and dil acids; miscible with ether
• Sol in acetone

Regulatory Status

Regulatory & Food Contact	EU Flavoring substances FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS Flavoring Agents
GHS notification summary	0.5% (1 / 187)

GHS Hazard Classification

GHS notification summary	0.5% (1 / 187)
Reported hazard statements	H226 (99.5%), H302 (98.9%), H311 (39.6%), H312 (44.9%), H315 (98.9%), H319 (98.9%), H332 (75.4%), H335 (84%)

Documented Uses

• Used as a chemical intermediate, dehydrohalogenation agent, tissue fixative for electron microscopy, and solvent for the manufacture of anthraquinones; [HSDB]
• Used as a chemical intermediate and as a dehydrohalogenation agent
• TISSUE FIXATIVE FOR ELECTRON MICROSCOPY
• SOLVENT FOR MANUFACTURE OF ANTHRAQUINONES (AS MIXTURE)
• Produced commercially from coal tar to some extent; also produced by Hantzsch pyridine synthesis: Hantzsch, Ann 215, 1 (1882); Mosher in Heterocyclic Compd vol 1, RC Elderfield, ed, (John Wiley, NY, 1950) pp 462-472...
• Produced...from acetone and ammonia: Mosher in Kirk-Othmer Encyclopedia of Chemical Technology vol II (NY, 1953) p 287, Compare Durkopf, Ber 21, 2713 (1888); from paraldehyde, acetone, ammonium acetate, and ammonia water: German patent 349,267; FRDL 14, 539...

Synonyms

2,4,6-Trimethylpyridine; 108-75-8; 2,4,6-COLLIDINE; s-Collidine; gamma-Collidine; Pyridine, 2,4,6-trimethyl-; sym-Collidine; 2,4,6-Kollidin; alpha,gamma,alpha'-Collidine; 7IE4BK5J5V; NSC-460; DTXSID1051561; RefChem:82156; pyridine, 2,4,6-trimethyl; DTXCID5030113; 203-613-3

Frequently Asked Questions

What are the CAS number and molecular formula of 2,4,6-Collidine?

CAS 108-75-8; molecular formula C8H11N; molecular weight 121.09 g/mol.

What other names is 2,4,6-Collidine known by?

2,4,6-Trimethylpyridine, 108-75-8, 2,4,6-COLLIDINE, s-Collidine, gamma-Collidine, Pyridine, 2,4,6-trimethyl-.

What is the regulatory status of 2,4,6-Collidine?

Documented regulatory listings: EU Flavoring substances; FDA Cumulative Estimated Daily Intake (CEDI): FCS; FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS.

Is 2,4,6-Collidine classified as hazardous?

0.5% of GHS notifications report no hazard classification (1 of 187).

What are the key physical properties of 2,4,6-Collidine?

Boiling Point: 170.4 °C; Melting Point: -44.5 °C; Flash Point: 58 °C; Flash Point: 136 °F.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.