羟基乙叉二膦酸

Description

1-Hydroxyethylidene-1,1-diphosphonic acid is identified by CAS 2809-21-4, molecular formula C2H8O7P2 and molecular weight 205.97 g/mol. UNII M2F465ROXU; ChEBI 4907; InChIKey DBVJJBKOTRCVKF-UHFFFAOYSA-N. Boiling Point: 578.8; Melting Point: 198-199; Melting Point: 105 °C.

Identification

CAS Registry Number	2809-21-4
PubChem CID	3305
Molecular formula	C2H8O7P2
Molecular weight	205.97 g/mol
IUPAC name	(1-hydroxy-1-phosphonoethyl)phosphonic acid
InChIKey	DBVJJBKOTRCVKF-UHFFFAOYSA-N
UNII (FDA)	M2F465ROXU
ChEBI ID	CHEBI:4907
ATC code (WHO)	M05BA01

Computed Descriptors

Molecular Weight	206.03
XLogP3	-3.7
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	205.97452659
Monoisotopic Mass	205.97452659
Topological Polar Surface Area	135
Heavy Atom Count	11
Formal Charge	0

Physical & Chemical Properties

Boiling Point	578.8
Melting Point	198-199
Melting Point	105 °C
Solubility	1.15e+01 g/L
LogP	-3.8

Physical description & handling notes

• CBI; Dry Powder; Liquid; Dry Powder; Liquid
• White odorless powder; [MSDSonline]
• Solid
• Etidronic acid is a first generation bisphosphonate that inhibits the action of osteoclasts, preventing bone resporption. It has a wide therapeutic index as overdoses are not associated with severe toxicity and a long duration of action as it slowly releases from the bone. Patients should be counselled regarding the risk of upper gastrointestinal adverse reactions.

Regulatory Status

Regulatory & Food Contact	FDA Substance added to food: BOILER WATER ADDITIVE FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS SEQUESTRANT: Food Additives HEDP does not pose a safety concern at the levels of residue that are expected to remain on foods at the time TRS 928-JECFA 63/26
GHS notification summary	1.6% (35 / 2257)

GHS Hazard Classification

GHS notification summary	1.6% (35 / 2257)
Reported hazard statements	H290 (34.6%), H302 (55.6%), H314 (23.9%), H318 (92.2%), H413 (25.7%), H371

Documented Uses

• Used as a sequestering and chelating agent; as a scale and corrosion inhibitor; as a bone resorptions inhibitor; [Merck Index]
• Use (kg; approx.) in Germany (2009): >1000
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
• EPA Safer Chemical Functional Use Classes -> Oxidants and Oxidant Stabilizers
• Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues

Synonyms

Etidronic acid; 2809-21-4; HEDP; 1-Hydroxyethylidene-1,1-diphosphonic acid; EHDP; Etidronsaeure; Turpinal SL; Acetodiphosphonic acid; Hydroxyethanediphosphonic acid; Acido etidronico; Acide etidronique; Oxyethylidenediphosphonic acid; Dequest 2015; Dequest Z 010; Ferrofos 510; Dequest 2010

Frequently Asked Questions

What are the CAS number and molecular formula of 1-Hydroxyethylidene-1,1-diphosphonic acid?

CAS 2809-21-4; molecular formula C2H8O7P2; molecular weight 205.97 g/mol.

What other names is 1-Hydroxyethylidene-1,1-diphosphonic acid known by?

Etidronic acid, 2809-21-4, HEDP, 1-Hydroxyethylidene-1,1-diphosphonic acid, EHDP, Etidronsaeure.

What is the regulatory status of 1-Hydroxyethylidene-1,1-diphosphonic acid?

Documented regulatory listings: FDA Substance added to food: BOILER WATER ADDITIVE; FDA Cumulative Estimated Daily Intake (CEDI): FCS; FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS.

Is 1-Hydroxyethylidene-1,1-diphosphonic acid classified as hazardous?

1.6% of GHS notifications report no hazard classification (35 of 2257).

What are the key physical properties of 1-Hydroxyethylidene-1,1-diphosphonic acid?

Boiling Point: 578.8; Melting Point: 198-199; Melting Point: 105 °C; Solubility: 1.15e+01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.