DL-2-羟基-4-(甲硫基)丁酸

Description

2-hydroxy-4-(methylthio)butyric acid · CAS 583-91-5 · C5H10O3S. UNII Z94465H1Y7. Melting Point: 250 °C; Flash Point: 250 °F (USCG, 1999); Density: 1.21 to 1.23 (USCG, 1999).

Identification

CAS Registry Number	583-91-5
PubChem CID	11427
Molecular formula	C5H10O3S
IUPAC name	2-hydroxy-4-methylsulfanylbutanoic acid
UNII (FDA)	Z94465H1Y7

Computed Descriptors

Molecular Weight	150.20
XLogP3	0.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	150.03506535
Monoisotopic Mass	150.03506535
Topological Polar Surface Area	82.8
Heavy Atom Count	9
Formal Charge	0

Physical & Chemical Properties

Melting Point	250 °C
Flash Point	250 °F (USCG, 1999)
Density	1.21 to 1.23 (USCG, 1999)
Vapor Pressure	16.0 [mmHg]
Autoignition Temperature	320 °F (USCG, 1999)
Collision Cross Section	167.3 Ų [M-H]-

Physical description & handling notes

• 2-hydroxy-4-(methylthio)-butanoic acid is a light brown liquid. (USCG, 1999)
• Light brown liquid; [CAMEO] Light brown to brown liquid with an odor of sulfur; [MSDSonline]
• Solid

GHS Hazard Classification

Reported hazard statements	H315 (100%), H318 (100%), H335 (20%), H412 (60%), H303, H313

Documented Uses

• Methionine hydroxy analog is used as a livestock dietary supplement; [Merck Index]
• Farming (Feed Additives) [Category: Industry]
• BLAKE, WINEMAN, US PATENTS 2,745,745 AND 2,938,053 (1956 AND 1960 TO MONSANTO)
• Butanoic acid, 2-hydroxy-4-(methylthio)-: ACTIVE
• CHICK LIVER HOMOGENATES CATALYZED THE OXIDATION OF 2-HYDROXY-4-(METHYLTHIO)BUTANOIC ACID TO KETOMETHIONINE & BOTH CHICK LIVER SUPERNATANTS & RAT LIVER SUPERNATANTS CONVERTED KETOMETHIONINE TO THE HYDROXY DERIVATIVE OR TO METHIONINE.
• IN RAT TISSUE, BOTH FLAVINE COENZYME & GLUTAMINE ARE REQUIRED FOR THE CONVERSION OF 2-HYDROXY-4-METHYLTHIOBUTYRIC ACID INTO METHIONINE. PER GRAM OF TISSUE, THE KIDNEY POSSESSES GREATER CONVERSION ACTIVITY THAN THE LIVER, BRAIN, SMALL INTESTINE, & MUSCLE, ALTHOUGH ON A TOTAL ORGAN BASIS THE LIVER IS THE MOST IMPORTANT. MOST OF THE CONVERSION ACTIVITY IS LOCATED IN THE SUPERNATANT FRACTION OF THE LIVER.

Synonyms

2-Hydroxy-4-methylthiobutanoic acid; alpha-Hydroxy-gamma-methylmercaptobutyric acid; RefChem:585800; 4-methylthio-2-hydroxybutyrate; alpha-hydroxy-gamma-methylthiobutyrate; 2-Hydroxy-4-(methylthio)butyric acid; 583-91-5; Desmeninol; Alimet; 2-Hydroxy-4-(methylthio)butanoic acid; Desmeninol [INN]; Butanoic acid, 2-hydroxy-4-(methylthio)-; MHA acid; 2-hydroxy-4-(methylsulfanyl)butanoic acid; 2-hydroxy-4-methylsulfanylbutanoic acid; MHA-FA

Frequently Asked Questions

What are the CAS number and molecular formula of 2-hydroxy-4-(methylthio)butyric acid?

CAS 583-91-5; molecular formula C5H10O3S; molecular weight — g/mol.

What other names is 2-hydroxy-4-(methylthio)butyric acid known by?

2-Hydroxy-4-methylthiobutanoic acid, alpha-Hydroxy-gamma-methylmercaptobutyric acid, RefChem:585800, 4-methylthio-2-hydroxybutyrate, alpha-hydroxy-gamma-methylthiobutyrate, 2-Hydroxy-4-(methylthio)butyric acid.

Is 2-hydroxy-4-(methylthio)butyric acid classified as hazardous?

Hazard statements reported: H315, H318, H335, H412, H303.

What are the key physical properties of 2-hydroxy-4-(methylthio)butyric acid?

Melting Point: 250 °C; Flash Point: 250 °F (USCG, 1999); Density: 1.21 to 1.23 (USCG, 1999); Vapor Pressure: 16.0 [mmHg].

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.