硫酸阿巴卡韦

Description

Abacavir Sulfate · CAS 188062-50-2 · C28H38N12O6S. UNII J220T4J9Q2. Solubility: In water, 77,000 mg/l @ 25 °C; LogP: log Kow = 1.2 @ 25 °C.

Identification

CAS Registry Number	188062-50-2
PubChem CID	441384
Molecular formula	C28H38N12O6S
IUPAC name	bis([(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol);sulfuric acid
UNII (FDA)	J220T4J9Q2

Computed Descriptors

Molecular Weight	670.7
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	8
Exact Mass	670.27579815
Monoisotopic Mass	670.27579815
Topological Polar Surface Area	287
Heavy Atom Count	47
Formal Charge	0
Complexity	496

Physical & Chemical Properties

Solubility	In water, 77,000 mg/l @ 25 °C
LogP	log Kow = 1.2 @ 25 °C

Physical description & handling notes

• White to off-white solid
• VP: 3.1X10-13 mm Hg @ 25 °C /Estimated/ /Abacavir/
• Henry's Law constant = 1.9X10-16 atm-cu m/mol @ 25 °C /Estimated/ /Abacavir/
• UV max: 296, 255 (epsilon=14000, 10700), pH = 1; 284, 259 (epsilon=15900, 9200) pH = 7 /Abacavir/
• Hydroxyl radical reaction rate constant = 2.6X10-10 cu cm/molec-sec @ 25 °C /Estimated/ /Abacavir/
• Abacavir sulfate: Oral: solution, 20 mg (of abacavir per ml, Ziagen (with parabens), GlaxoSmithKline; Tablets: 300 mg (of abacavir), Ziagen, GlaxoSmithKline

GHS Hazard Classification

Reported hazard statements	H317 (12.8%), H318 (10.6%), H341 (14.9%), H351 (89.4%), H361 (89.4%)

Documented Uses

• Preparation: S. M. Daluge, EP 349242 (1990 to Wellcome Foundation); S. M. Daluge et al, US 5034394 (1991 to Burroughs Wellcome).
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; Reverse Transcriptase Inhibitors
• Abacavir (brand name: Ziagen) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV in adults, children, and infants. Abacavir is always used in combination with other HIV medicines.
• Nucleoside Reverse Transcriptase Inhibitor (NRTIs)
• Abacavir is indicated, in combination with other agents, for treatment of HIV-1 infection. /Included in US product labeling/
• Lactic acidosis and severe hepatomegaly with steatosis (sometimes fatal) have been reported rarely in patients receiving abacavir and also have been reported in patients receiving dideoxynucleoside reverse transcriptase inhibitors. Most reported cases have involved women; obesity and long-term therapy with a nucleoside reverse transcriptase inhibitor also may be risk factors. Increased serum concentrations of Gamma-glutamyltransferase (GGT, GGPT) have been reported in patients receiving abacavir.

Synonyms

Abacavir sulfate; 188062-50-2; Abacavir sulphate; 1592U89 sulfate; Abacavir Hemisulfate; Abamune; DRG-0257; Abacavir (as sulfate); Abacaviri sulfas; NSC-760063; J220T4J9Q2; CHEBI:2361; TRIUMEQ COMPONENT ABACAVIR SULFATE; TRIZIVIR COMPONENT ABACAVIR SULFATE; RefChem:56278; DRG0257

Frequently Asked Questions

What are the CAS number and molecular formula of Abacavir Sulfate?

CAS 188062-50-2; molecular formula C28H38N12O6S; molecular weight — g/mol.

What other names is Abacavir Sulfate known by?

Abacavir sulfate, 188062-50-2, Abacavir sulphate, 1592U89 sulfate, Abacavir Hemisulfate, Abamune.

Is Abacavir Sulfate classified as hazardous?

Hazard statements reported: H317, H318, H341, H351, H361.

What are the key physical properties of Abacavir Sulfate?

Solubility: In water, 77,000 mg/l @ 25 °C; LogP: log Kow = 1.2 @ 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.