阿西替尼

Description

Axitinib · CAS 319460-85-0 · C22H18N4OS. UNII C9LVQ0YUXG. LogP: 3.8; Dissociation Constants: 4.8.

Identification

CAS Registry Number	319460-85-0
PubChem CID	6450551
Molecular formula	C22H18N4OS
IUPAC name	N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
UNII (FDA)	C9LVQ0YUXG

Computed Descriptors

Molecular Weight	386.5
XLogP3	4.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	386.12013238
Monoisotopic Mass	386.12013238
Topological Polar Surface Area	96
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

LogP	3.8
Dissociation Constants	4.8

Physical description & handling notes

• In aqueous media with a pH between 1.1 to 7.8, axitinib has a solubility of over 0.2 μg/mL.
• Axitinib prevents the progression of cancer by inhibiting angiogenesis and blocking tumor growth.

GHS Hazard Classification

Reported hazard statements	H302 (53.4%), H341 (43.8%), H361 (43.8%), H373 (43.8%), H400 (56.2%)

Documented Uses

• Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• • Renal cell carcinoma (a type of kidney cancer) that is advanced. It is used:
• • With avelumab or pembrolizumab as the first treatment.
• • Alone in patients whose cancer did not get better after one treatment with systemic therapy.
• Axitinib is also being studied in the treatment of other types of cancer.

Synonyms

Axitinib; 319460-85-0; Inlyta; AG-13736; axitinibum; C9LVQ0YUXG; DTXSID3049049; AG013736; NSC-757441; N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide; DTXCID8028975; CHEBI:66910; Benzamide, N-methyl-2-((3-((E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)thio)-; N-methyl-2-({3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide; Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazo)-6-yl)thio)-

Frequently Asked Questions

What are the CAS number and molecular formula of Axitinib?

CAS 319460-85-0; molecular formula C22H18N4OS; molecular weight — g/mol.

What other names is Axitinib known by?

Axitinib, 319460-85-0, Inlyta, AG-13736, axitinibum, C9LVQ0YUXG.

Is Axitinib classified as hazardous?

Hazard statements reported: H302, H341, H361, H373, H400.

What are the key physical properties of Axitinib?

LogP: 3.8; Dissociation Constants: 4.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.