AZD-9291(甲磺酸盐)

Description

AZD-9291(Mesylate) · CAS 1421373-66-1 · C29H37N7O5S. UNII RDL94R2A16.

Identification

CAS Registry Number	1421373-66-1
PubChem CID	78357807
Molecular formula	C29H37N7O5S
IUPAC name	N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
UNII (FDA)	RDL94R2A16

Computed Descriptors

Molecular Weight	595.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	595.25768848
Monoisotopic Mass	595.25768848
Topological Polar Surface Area	150
Heavy Atom Count	42
Formal Charge	0
Complexity	845

GHS Hazard Classification

Reported hazard statements	H302 (75%), H317 (75%), H360 (25%), H361 (75%), H362 (25%), H372 (75%), H400 (75%), H410 (75%)

Documented Uses

• Osimertinib mesylate is approved to treat:
• • Non-small cell lung cancer that has an abnormal EGFR gene. It is used in adults:
• • who have had surgery to remove the cancer, to help keep the cancer from coming back after surgery
• • with stage IIIA, stage IIIB, or stage IIIC cancer that cannot be removed by surgery and did not get worse during or after platinum-based chemoradiation therapy
• • as the first treatment for cancer that has spread to other parts of the body
• • with pemetrexed disodium and platinum-based chemotherapy as the first treatment for cancer that has spread to other parts of the body

Synonyms

Osimertinib mesylate; 1421373-66-1; AZD-9291 mesylate; AZD9291 mesylate; Mereletinib mesylate; osimertinib mesilate; Mereletinib mesilate; RDL94R2A16; CHEBI:90948; DTXSID101027822; RefChem:58258; DTXCID601513393; AZD-9291 (Mesylate); Tagrisso; Osimertinib mesylate [USAN]; AZD 9291 mesylate

Frequently Asked Questions

What are the CAS number and molecular formula of AZD-9291(Mesylate)?

CAS 1421373-66-1; molecular formula C29H37N7O5S; molecular weight — g/mol.

What other names is AZD-9291(Mesylate) known by?

Osimertinib mesylate, 1421373-66-1, AZD-9291 mesylate, AZD9291 mesylate, Mereletinib mesylate, osimertinib mesilate.

Is AZD-9291(Mesylate) classified as hazardous?

Hazard statements reported: H302, H317, H360, H361, H362.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.