acenocoumarol

Description

acenocoumarol · CAS 152-72-7 · C19H15NO6. UNII I6WP63U32H. Melting Point: 196-199; Melting Point: 196-199 °C; Melting Point: 197 °C.

Identification

CAS Registry Number	152-72-7
PubChem CID	54676537
Molecular formula	C19H15NO6
IUPAC name	4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]chromen-2-one
UNII (FDA)	I6WP63U32H

Computed Descriptors

Molecular Weight	353.3
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	353.08993720
Monoisotopic Mass	353.08993720
Topological Polar Surface Area	109
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	196-199
Melting Point	196-199 °C
Melting Point	197 °C
Solubility	In water, 9.39 mg/l @ 20 to 25 °C
Solubility	1.06e-02 g/L
LogP	1.98
LogP	log Kow = 1.98
Dissociation Constants	pKa = 5.05

Physical description & handling notes

• Solid
• Crystals
• White crystaline powder
• OFF-WHITE TO LIGHT-TAN POWDER
• Odorless
• Tasteless

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (82.6%), H319 (82.6%), H335 (82.6%), H360 (13%), H361 (82.6%)

Documented Uses

• Acenocoumarol is an anticoagulant drug derived from coumarin. (L1261) For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.
• Prepn: W. Stoll, F. Litvan, US 2648682 (1953 to Geigy).
• For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.
• Breast Feeding; Lactation; Anticoagulants
• ACTIONS & USES OF ACENOCOUMAROL ARE THOSE OF DICOUMAROL. ... DRUG INTERACTIONS ARE SAME AS THOSE OF DICOUMAROL.
• ACENOCOUMAROL IS MOST POTENT OF PROTHROMBOPENIC ANTICOAGULANTS.

Synonyms

ACENOCOUMAROL; 152-72-7; Acenocoumarin; Nicoumalone; Sintrom; Nitrowarfarin; Nitrovarfarian; Sinthrome; Acenocumarol; Nicumalon; Sincoumar; Sinkumar; Ascumar; Syntrom; Zotil; Acenokumarin

Frequently Asked Questions

What are the CAS number and molecular formula of acenocoumarol?

CAS 152-72-7; molecular formula C19H15NO6; molecular weight — g/mol.

What other names is acenocoumarol known by?

ACENOCOUMAROL, 152-72-7, Acenocoumarin, Nicoumalone, Sintrom, Nitrowarfarin.

Is acenocoumarol classified as hazardous?

Hazard statements reported: H302, H315, H319, H335, H360.

What are the key physical properties of acenocoumarol?

Melting Point: 196-199; Melting Point: 196-199 °C; Melting Point: 197 °C; Solubility: In water, 9.39 mg/l @ 20 to 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.