Avilamycin

Description

Avilamycin · CAS 11051-71-1 · C61H88Cl2O32. UNII 720WDX56D3. Melting Point: 188-189.5 °C.

Identification

Computed Descriptors

Physical & Chemical Properties

Physical description & handling notes

• Colorless, needle-shaped crystals from acetone-ether
• Colorless needles from chloroform/petroleum ether; MW: 1404.25; MP: 181-182 °C (1-2.H2O). UV max (methanol): 227, 286 nm (log epsilon 4.12, 3.33) /Avilamycin A/
• Specific optical rotation at 20 °C/D = +0.8 deg (c = 1.165 in absolute ethanol); -7.7 deg (c = 1.083 in chloroform)
• Oligosaccharide antibiotics are sensitive to acid pH because of the ortho-ester linkages. Acidic phenolic group makes them relatively unstable to handling conditions.
• Dihydrate; colorless fine plates from acetone/ether; MP: 188-189 °C. Specific optical rotation at 20 °C/D: -4.8 deg (C = 1.44 in chloroform). UV Max (methanol): 228, 284 nm (log epsilon 4.12, 3.33) /Avilamycin C/
• Reactive groups are the glycosidic linkages, the hydroxyl groups, the carbonyl groups, and the phenolic groups.

Regulatory Status

GHS Hazard Classification

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes
• Polyether antibiotic complex produced by Streptromyces viridochromogenes, ETH 23575 (NRRL 2860) ... Isoln: E. Gaeumann et al., German patent 1116864; eidem, USA patent 3131126 (1961, 1964 both to Ciba-Geigy).
• Avilamycin A is the main component; avilamycins B through N are also known and are derivatives of A differing at the C-45 linkage and/or the C-56 ketone adduct.
• MEDICATION (VET): Avilamycin is mainly active against Gram-positive bacteria, including Bacillus spp., Clostridium spp., Corynebacterium bovis, Enterococcus spp., Lactobacillus spp., Listeria monocytogenes, Micrococcus luteus, Staphylococcus aureus and Streptococcus spp. Avilamycin is intended for use as a veterinary medicine in chickens, turkeys, pigs and rabbits to control bacterial enteric infections.
• MEDICATION (VET): For the reduction in incidence and overall severity of diarrhea in the presence of pathogenic Escherichia coli in groups of weaned pigs. /Included in US product label/

Synonyms

Avilamycin; Avilamycina; Avilamycine; Avilamycinum; 11051-71-1; LY 048 740; DTXSID40891398; 720WDX56D3; avilamicina; Inteprity; Kavault; RefChem:57998; DTXCID701030518; LY-048740; Surmax; C61H88Cl2O32

Frequently Asked Questions

What are the CAS number and molecular formula of Avilamycin?

CAS 11051-71-1; molecular formula C61H88Cl2O32; molecular weight — g/mol.

What other names is Avilamycin known by?

Avilamycin, Avilamycina, Avilamycine, Avilamycinum, 11051-71-1, LY 048 740.

What is the regulatory status of Avilamycin?

Documented regulatory listings: ANTIMICROBIAL_AGENT: Veterinary Drug; JECFA ADI: 0-0.002 mg/kg bw; TRS 954- JECFA 70.

Is Avilamycin classified as hazardous?

Hazard statements reported: H319.

What are the key physical properties of Avilamycin?

Melting Point: 188-189.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.