安普那韦

Name: 安普那韦
Brand: 济南圣和化工有限公司

CAS 161814-49-9C25H35N3O6SMW 505.6

安普那韦，CAS 登记号 161814-49-9，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于医药中间体及原料药。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号161814-49-9

分子式C25H35N3O6S

分子量505.6

LogPlog Kow = 2.2 @ 25 °C /Estimated/

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域医药中间体及原料药

类别医药中间体及原料药

用途与场景

医药中间体及原料药

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

文件与支持

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常见问题

在哪里能查到安普那韦的 CAS 号？

本页已列出安普那韦的 CAS 号：161814-49-9，可与随货 COA 核对。

可以提供哪些规格和包装？

常见纯度为按批次COA提供(不公开发布)，包装形式为按订单/批次确认(不公开发布)，特殊规格可在询价时说明。

安普那韦一般用在什么产品里？

主要涉及医药中间体及原料药。

下单流程是怎样的？

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PubChem 公开数据

Description

AMPRENAVIR · CAS 161814-49-9 · C25H35N3O6S. UNII 5S0W860XNR. Solubility: In water, 40 mg/l @ 25 °C; Solubility: 4.91e-02 g/L; Vapor Pressure: 9.9X10-18 mm Hg @ 25 °C /Estimated/.

Identification

CAS Registry Number	161814-49-9
PubChem CID	65016
Molecular formula	C25H35N3O6S
IUPAC name	[(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
UNII (FDA)	5S0W860XNR

Computed Descriptors

Molecular Weight	505.6
XLogP3	2.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	12
Exact Mass	505.22465702
Monoisotopic Mass	505.22465702
Topological Polar Surface Area	140
Heavy Atom Count	35
Formal Charge	0

Physical & Chemical Properties

Solubility	In water, 40 mg/l @ 25 °C
Solubility	4.91e-02 g/L
Vapor Pressure	9.9X10-18 mm Hg @ 25 °C /Estimated/
LogP	log Kow = 2.2 @ 25 °C /Estimated/

Physical description & handling notes

Solid
Henry's Law constant = 1.6X10-23 atm-cu m/mol @ 25 °C /Estimated/
Hydroxyl radical reaction rate constant = 1.1X10-10 cu cm/molec sec @ 25 °C /Estimated/
Oral: Capsules, liquid-filled, 50 mg, Agenerase (with propylene glycol 19 mg and vitamin E 36 units), GlaxoSmithKline; 150 mg, Agenerase (with propylene glycol and vitamin E 109 units), GlaxoSmithKline.Solution: 15 mg/ml, Agenerase (with propylene glycol 550 mg/ml, and vitamin E 46 units/ml), GlaxoSmithKline

GHS Hazard Classification

Reported hazard statements	H351 (100%), H361 (100%), H412 (100%)

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Documented Uses

For the treatment of HIV-1 infection in combination with other antiretroviral agents.
Preparation: ... R.D. Tung et al, US 5585397 (1994, 1996 both to Vertex)
Amprenavir is indicated in combination with other antiretroviral agents in the treatment of HIV-1 infection. /Included in US product labeling/
Amprenavir is a human immunodeficiency virus (HIV)-protease inhibitor. The use of amprenavir for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in combination with other antiretrovirals is based on analyses of plasma HIV-RNA levels and CD4 cell counts in controlled studies of up to 24 weeks duration. Results from controlled trials evaluating the long-term suppression of HIV-RNA or disease progression with amprenavir have not yet been obtained.
Patients being treated with amprenavir oral solution should be closely monitored for propylene glycol associated side effects including hemolysis, hyperosmolality, lactic acidosis, renal toxicity, seizures, stupor, and tachycardia.
The pharmacokinetics of amprenavir do not differ between females and males or between Blacks and non-Blacks. However, amprenavir oral solution contains a large amount of propylene glycol and because Asians, Eskimos, Native Americans, and women have a decreased ability to metabolize this compound, they may have an increased risk of developing propylene glycol-associated side effects.

Synonyms

amprenavir; 161814-49-9; Agenerase; VX-478; Prozei; 141W94; KVX-478; Vertex VX478; VX 478; 5S0W860XNR; CHEBI:40050; J05AE05; Tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate; KVX 478; DTXSID5046061; Amprenavirum

Frequently Asked Questions

What are the CAS number and molecular formula of AMPRENAVIR?

CAS 161814-49-9; molecular formula C25H35N3O6S; molecular weight — g/mol.

What other names is AMPRENAVIR known by?

amprenavir, 161814-49-9, Agenerase, VX-478, Prozei, 141W94.

Is AMPRENAVIR classified as hazardous?

Hazard statements reported: H351, H361, H412.

What are the key physical properties of AMPRENAVIR?

Solubility: In water, 40 mg/l @ 25 °C; Solubility: 4.91e-02 g/L; Vapor Pressure: 9.9X10-18 mm Hg @ 25 °C /Estimated/; LogP: log Kow = 2.2 @ 25 °C /Estimated/.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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