Albiglutide

Description

Albiglutide · CAS 782500-75-8 · C148H223N39O46. UNII 5E7U48495E.

Identification

Computed Descriptors

Physical description & handling notes

• White to yellow powder
• Chemical stability: Material is stable under normal conditions.
• Hazardous decomposition products: Irritating and/or toxic fumes and gases may be emitted upon the products decomposition.
• Solvent is clear, colorless; reconstituted solution is yellow
• Table: Albiglutide Preparations [Table#8276]
• Eperzan

Documented Uses

• Tanzeum is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. /Included in US product label/
• Albiglutide is produced in Saccharomyces cerevisiae using recombinant deoxyribonucleic acid (DNA) technology. The albiglutide drug substance manufacturing process consists of a series of steps which include cell culture, harvest, and purification stages.
• Preparation: C. A. Rosen, W. A. Haseltine, World Intellectual Property Organization patent 03059934; C. A. Rosen et al., USA patent 7141547 (2003, 2006 both to Human Genome Sciences).
• Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
• Albiglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents. There have been no published reports of hepatotoxicity attributed to albiglutide therapy.
• /BOX WARNING/ Carcinogenicity of albiglutide could not be assessed in rodents, but other glucagon-like peptide-1 (GLP-1) receptor agonists have caused thyroid C-cell tumors in rodents at clinically relevant exposures. Human relevance of GLP-1 receptor agonist induced C-cell tumors in rodents has not been determined. It is unknown whether Tanzeum causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.

Synonyms

albiglutidum; Albiglutida; RefChem:141; A10BJ04; Albiglutide (genetical recombination); 5E7U48495E; 782500-75-8; Albiglutide; Eperzan; GSK-716155; GSK716155; Tanzeum; CHEBI:78425; SCHEMBL29349999; CHEBI:136045; HGB50075

Frequently Asked Questions

What are the CAS number and molecular formula of Albiglutide?

CAS 782500-75-8; molecular formula C148H223N39O46; molecular weight — g/mol.

What other names is Albiglutide known by?

albiglutidum, Albiglutida, RefChem:141, A10BJ04, Albiglutide (genetical recombination), 5E7U48495E.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.