阿佐塞米

阿佐塞米（CAS 27589-33-9）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• Solid
• Diuretic affects upon oral administration match those of furosemide. However, upon intravenous administration azosemide displays 5.5 to 8 times greater effect.

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Agents that promote the excretion of urine through their effects on kidney function.
• Peak plasma concentrations are achieved in 3-4 hours when azosemide is administered to healthy humans in a fasting state. There is an absorption lag time of approximately 1 hour. Oral bioavailability estimated to be 20.4%
• Total body clearance 112ml/min. Renal clearance 41.6ml/min. Actively secreted in the renal proximal tubule of humans. This may or may not involve a nonspecific organic acid secretory pathway. There is thus a potential for disease states and other organic acids such as NSAIDs which affect the organic acid transport pathway to affect the efficacy of azosemide.
• Poor affinity for human tissue. Small apparent post-pseudodistribution Vd of 0.262 l/kg.
• > 95% 4% protein binding to 4% human serum albumin at azosemide concentrations of 10-100ug/ml, using equilibrium dialysis.
• Considerable first pass metabolism which makes parentral administration more effective than oral administration. Eleven metabolites of azosemide were found in rats, but only azosemide and its glucuronide were detected in humans.

它在各数据库里的别名

azosemide; 27589-33-9; Azosemid; Diart; Azosemida; Azosemidum; Luret; DTXSID7046910; MR40VT1L8Z; 2-Chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenylsulfanilamide; Benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-; 5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole; DTXCID5026910; CHEBI:31248; 2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzene-1-sulfonamide; 2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzene-1-sulfonamide

计算机算出的分子描述符

数据库摘要

Azosemide · CAS 27589-33-9 · C12H11ClN6O2S2. UNII MR40VT1L8Z. 熔点: 219.5 °C.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。