阿氯芬酸

Description

Alclofenac · CAS 22131-79-9 · C11H11ClO3. UNII M9CP5H21N8. LogP: 2.97.

Identification

CAS Registry Number	22131-79-9
PubChem CID	30951
Molecular formula	C11H11ClO3
IUPAC name	2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
UNII (FDA)	M9CP5H21N8

Computed Descriptors

Molecular Weight	226.65
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	226.0396719
Monoisotopic Mass	226.0396719
Topological Polar Surface Area	46.5
Heavy Atom Count	15
Formal Charge	0

Physical & Chemical Properties

LogP	2.97

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies.
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
• M01 - Antiinflammatory and antirheumatic products
• M01A - Antiinflammatory and antirheumatic products, non-steroids
• M01AB - Acetic acid derivatives and related substances

Synonyms

alclofenac; 22131-79-9; Medifenac; Prinalgin; Mervan; Alclophenac; Allopydin; Reufenac; Neosten; Neoston; Zumaril; Alclofenaco; Epinal; Alclofenacum; [4-(Allyloxy)-3-chlorophenyl]acetic acid; W 7320

Frequently Asked Questions

What are the CAS number and molecular formula of Alclofenac?

CAS 22131-79-9; molecular formula C11H11ClO3; molecular weight — g/mol.

What other names is Alclofenac known by?

alclofenac, 22131-79-9, Medifenac, Prinalgin, Mervan, Alclophenac.

Is Alclofenac classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Alclofenac?

LogP: 2.97.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.