布瑞哌唑

Description

Brexpiprazole · CAS 913611-97-9 · C25H27N3O2S. UNII 2J3YBM1K8C. Boiling Point: 675.2; Melting Point: 135.1.

Identification

CAS Registry Number	913611-97-9
PubChem CID	11978813
Molecular formula	C25H27N3O2S
IUPAC name	7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]-1H-quinolin-2-one
UNII (FDA)	2J3YBM1K8C

Computed Descriptors

Molecular Weight	433.6
XLogP3	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	433.18239829
Monoisotopic Mass	433.18239829
Topological Polar Surface Area	73.1
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

Boiling Point	675.2
Melting Point	135.1

GHS Hazard Classification

Reported hazard statements	H302 (96.6%), H351 (98.3%), H360 (96.6%), H362 (98.3%), H372 (96.6%), H400 (96.6%), H410 (98.3%), H361 (100%)

Documented Uses

• Brexpiprazole is indicated as adjunctive therapy to antidepressants for the treatment of major depressive disorder in adults. It is also indicated for the treatment of schizophrenia in patients 13 years of age and older. Brexpiprazole is also indicated for the treatment of agitation associated with dementia due to Alzheimer’s disease; however, it is not indicated as an as-needed (“prn”) treatment for this condition.
• Brexpiprazole is an atypical antipsychotic used in the treatment of schizophrenia and major depressive disorders. Brexpiprazole has been associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antipsychotic Agents; Serotonin Agents; Dopamine Agonists
• Avoid St. John's Wort. This herb induces the CYP3A metabolism of brexpiprazole and may reduce its serum concentration. The dose of Brexpiprazole should be doubled if administered with St. John's wort.
• Take with or without food. Food does not significantly affect brexpiprazole exposure.
• Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.

Synonyms

BREXPIPRAZOLE; 913611-97-9; Rexulti; OPC-34712; OPC 34712; brexpiprazol; 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]-1H-quinolin-2-one; 2J3YBM1K8C; 7-(4-(4-(1-Benzothiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one; DTXSID40238527; 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}-1,2-dihydroquinolin-2-one; brexpiprazolum; 7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butoxy)-1H-quinolin-2-one; 7-{4-[4-(1-Benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one; 7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butoxy)-1,2-dihydroquinolin-2-one; RefChem:58868

Frequently Asked Questions

What are the CAS number and molecular formula of Brexpiprazole?

CAS 913611-97-9; molecular formula C25H27N3O2S; molecular weight — g/mol.

What other names is Brexpiprazole known by?

BREXPIPRAZOLE, 913611-97-9, Rexulti, OPC-34712, OPC 34712, brexpiprazol.

Is Brexpiprazole classified as hazardous?

Hazard statements reported: H302, H351, H360, H362, H372.

What are the key physical properties of Brexpiprazole?

Boiling Point: 675.2; Melting Point: 135.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.