benznidazole

Description

benznidazole · CAS 22994-85-0 · C12H12N4O3. UNII YC42NRJ1ZD. Melting Point: 190-192; LogP: 0.85.

Identification

CAS Registry Number	22994-85-0
PubChem CID	31593
Molecular formula	C12H12N4O3
IUPAC name	N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
UNII (FDA)	YC42NRJ1ZD

Computed Descriptors

Molecular Weight	260.25
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	260.09094026
Monoisotopic Mass	260.09094026
Topological Polar Surface Area	92.7
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	190-192
LogP	0.85

Physical description & handling notes

• >39 [ug/mL] (The mean of the results at pH 7.4)
• Benznidazole is a trypanocidal agent which kills the causative organism in Chagas disease, *Trypanosoma cruzi*.

GHS Hazard Classification

Reported hazard statements	H315 (97.6%), H319 (97.6%), H335 (97.6%)

Documented Uses

• For use in the treatment of Chagas disease in children 2-12 years of age.
• Benznidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of Chagas disease (American trypanosomiasis). Benznidazole is a nitroimidazole similar to metronidazole and is associated with serum enzyme elevations during therapy in up to 10% of patients but has not linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antiparasitic Agents; Antiprotozoal Agents; Nitroimidazoles; Trypanocidal Agents
• Oral - Solid - tablet: 100 mg (scored); 50 mg (scored); 12.5 mg
• Benznidazole is an antiprotozoal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of Chagas disease caused by infection with the parasiteTrypanosoma cruzi. Benznidazole is FDA-approved for use in children 2 to 12 years of age.
• Chagas disease can be an opportunistic infection (OI) of HIV.

Synonyms

BENZNIDAZOLE; 22994-85-0; Benznidazol; Radanil; Benzonidazole; Rochagan; benzonidazol; Benznidazolum; N-benzyl-2-(2-nitroimidazol-1-yl)acetamide; Ro 07-1051; 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-; N-Benzyl-2-nitroimidazole-1-acetamide; 2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide; N-Benzyl-2-nitroimidazol-1-yl-acetamide; Imidazole-1-acetamide, N-benzyl-2-nitro-; DTXSID9046570

Frequently Asked Questions

What are the CAS number and molecular formula of benznidazole?

CAS 22994-85-0; molecular formula C12H12N4O3; molecular weight — g/mol.

What other names is benznidazole known by?

BENZNIDAZOLE, 22994-85-0, Benznidazol, Radanil, Benzonidazole, Rochagan.

Is benznidazole classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of benznidazole?

Melting Point: 190-192; LogP: 0.85.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.