BENZIMIDAVIR

Description

BENZIMIDAVIR · CAS 176161-24-3 · C15H19Cl2N3O4. UNII PTB4X93HE1.

Identification

Computed Descriptors

GHS Hazard Classification

Documented Uses

• Maribavir is indicated for the treatment of post-transplant cytomegalovirus (CMV) infection (following hematopoietic stem cell transplant or solid organ transplant) which is refractory to standard treatment with [ganciclovir], [valganciclovir], [cidofovir], or [foscarnet]. In the US, patients receiving the treatment should weigh more than 35 kg and be at least 12 years old. In Canada and Europe, maribavir is only approved in adults.
• Maribavir is an orally available, antiviral agent which inhibits the pUL97 kinase of cytomegalovirus (CMV) and is used to treat refractory forms of post-transplant CMV infection. Maribavir has been associated with low rates of mild-to-moderate serum aminotransferase elevations during therapy but has not been linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antiviral Agents
• Avoid St. John's Wort. Co-administration with St. John's wort decreases serum levels of maribavir and may decrease its therapeutic efficacy.
• Take with or without food. The co-administration of food with maribavir does not significantly affect its disposition.
• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Synonyms

Maribavir; 176161-24-3; Benzimidavir; livtencity; 1263W94; Camvia; maribavirum; BW-1263W94; GW-257406X; (2S,3S,4R,5S)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol; GW-1263; PTB4X93HE1; BW 1263W94; 1263-W-94; DTXSID60170091; GW257406X

Frequently Asked Questions

What are the CAS number and molecular formula of BENZIMIDAVIR?

CAS 176161-24-3; molecular formula C15H19Cl2N3O4; molecular weight — g/mol.

What other names is BENZIMIDAVIR known by?

Maribavir, 176161-24-3, Benzimidavir, livtencity, 1263W94, Camvia.

Is BENZIMIDAVIR classified as hazardous?

Hazard statements reported: H302, H318, H371.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.