Cortisone acetate

Description

Cortisone acetate · CAS 50-04-4 · C23H30O6. UNII 883WKN7W8X. Melting Point: 227-229; Melting Point: 222 °C; Solubility: 20.

Identification

CAS Registry Number	50-04-4
PubChem CID	5745
Molecular formula	C23H30O6
IUPAC name	[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
UNII (FDA)	883WKN7W8X

Computed Descriptors

Molecular Weight	402.5
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	402.20423867
Monoisotopic Mass	402.20423867
Topological Polar Surface Area	97.7
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Melting Point	227-229
Melting Point	222 °C
Solubility	20
Solubility	2.78e-02 g/L
LogP	2.1
LogP	2.10

Physical description & handling notes

• Solid
• 196.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H312 (73.9%), H332 (73.9%), H361 (87%)

Documented Uses

• Cortisone acetate is indicated to treat a wide variety of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.
• Take with food. Taking cortisone acetate with food may reduce gastrointestinal upset.
• Substances that reduce or suppress INFLAMMATION.
• Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]
• Corticosteroids are eliminated predominantly in the urine.
• Data regarding the clearance of cortisone acetate is not readily available.

Synonyms

CORTISONE ACETATE; 50-04-4; Cortisone 21-acetate; Cortone acetate; Cortisyl; Cortelan; Cortistab; Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-; Cortisone, 21-acetate; Cortisone aceticum; DTXSID0022858; NSC-49420; 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate; 883WKN7W8X; 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione; DTXCID502858

Frequently Asked Questions

What are the CAS number and molecular formula of Cortisone acetate?

CAS 50-04-4; molecular formula C23H30O6; molecular weight — g/mol.

What other names is Cortisone acetate known by?

CORTISONE ACETATE, 50-04-4, Cortisone 21-acetate, Cortone acetate, Cortisyl, Cortelan.

Is Cortisone acetate classified as hazardous?

Hazard statements reported: H312, H332, H361.

What are the key physical properties of Cortisone acetate?

Melting Point: 227-229; Melting Point: 222 °C; Solubility: 20; Solubility: 2.78e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.