Conjugated Estrogen

Description

Conjugated Estrogen · CAS 12126-59-9 · C18H19NaO5S. UNII 7XY8FW3E68.

Identification

Computed Descriptors

Physical description & handling notes

• Avoid exposure to heat, air, and moisture; any exposure will cause equilin content to lose potency
• When heated to decomposition it emits toxic fumes of /Sodium oxide/. /Equigyne/
• When heated to decomposition it emits acrid smoke and irritating fumes. /Premarin/
• CENESTIN tablets for oral administration, are available in 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg and 1.25 mg strengths of synthetic conjugated estrogens, A. Tablets also contain the following inactive ingredients: ethylcellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, polysorbate 80, pregelatinized starch, titanium dioxide, and triethyl citrate.
• For more Formulations/Preparations (Complete) data for ESTROGENIC SUBSTANCES, CONJUGATED (6 total), please visit the HSDB record page.

GHS Hazard Classification

Documented Uses

• Medicine, biochemical research, oral contraceptives /Estrogen/
• Complex mixture of natural estrogens obtained from equine urine or synthetically from estrone and equilin. Principal components are sodium estrone sulfate and sodium equilin sulfate; also known to contain 17alpha-dihydroequilin, 17alpha-estradiol, and 17beta-dihydroequilin as sodium sulfate conjugates.
• The term "conjugated estrogens" refers to mixtures of at least eight compounds, including sodium estrone sulfate and sodium equilin sulfate, that are derived wholly or in part from equine urine, are plant-based or are manufactured synthetically from estrone and equilin. Conjugated estrogens contain as concomitant components the sodium sulfate conjugates of 17alpha-dihydroequilin, 17beta-dihydroequilin and 17alpha-estradiol.
• For the treatment of moderate to severe vasomotor symptoms due to menopause and for treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.
• Hormones and Synthetic Substitutes:
• Conjugated estrogen therapy is indicated in the treatment of moderate to severe vasomotor symptoms due to menopause. /Included in US product label/

Synonyms

Cenestin; Estrogens, conjugated synthetic A; RefChem:55147; JM2621P2LS; Estrogens,conjugated synthetic a; Synthetic Conjugated Estrogens, A; SYNTHETIC CONJUGATED ESTROGENS A; 16680-47-0; Sodium equilin sulfate; Equilin sodium sulfate; Sodium equilin 3-monosulfate; Equilin 3-Sulfate Sodium Salt; 7XY8FW3E68; Estratab; Equilin 3-Sulfate Sodium Salt (Stabilized with TRIS, 50% w/w); sodium;[(9S,13S,14S)-13-methyl-17-oxo-9,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfate

Frequently Asked Questions

What are the CAS number and molecular formula of Conjugated Estrogen?

CAS 12126-59-9; molecular formula C18H19NaO5S; molecular weight — g/mol.

What other names is Conjugated Estrogen known by?

Cenestin, Estrogens, conjugated synthetic A, RefChem:55147, JM2621P2LS, Estrogens,conjugated synthetic a, Synthetic Conjugated Estrogens, A.

Is Conjugated Estrogen classified as hazardous?

Hazard statements reported: H350, H351, H360.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.