考比替尼

Description

Cobimetinib · CAS 934660-93-2 · C21H21F3IN3O2. UNII ER29L26N1X.

Identification

CAS Registry Number	934660-93-2
PubChem CID	16222096
Molecular formula	C21H21F3IN3O2
IUPAC name	[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
UNII (FDA)	ER29L26N1X

Computed Descriptors

Molecular Weight	531.3
XLogP3	3.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	531.06306
Monoisotopic Mass	531.06306
Topological Polar Surface Area	64.6
Heavy Atom Count	30
Formal Charge	0

Documented Uses

• Cobimetinib is indicated in combination with [vemurafenib] for the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. As a single agent, cobimetinib is also indicated for the treatment of adult patients with histiocytic neoplasms.
• Cobimetinib is a tyrosine kinase receptor inhibitor that is used in combination with vemurafenib as therapy for selected forms of advanced malignant melanoma. The combination of cobimetinib and vemurafenib is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; MEK Inhibitors
• Cobimetinib fumarate is approved to be used to treat:
• • Melanoma that cannot be removed by surgery or has spread to other parts of the body. It is used with vemurafenib in patients whose cancer has a certain mutation in the BRAF gene.
• • Histiocytic cancers. It is used alone in adults.

Synonyms

Cobimetinib; 934660-93-2; GDC-0973; XL518; Cotellic; GDC 0973; Xl-518; RG7420; XL 518; RG 7420; ER29L26N1X; CHEBI:90851; DTXSID60239435; 1-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl}-3-[(2S)-piperidin-2-yl]azetidin-3-ol; cobimetinibum; 1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-((2S)-piperidin-2-yl)azetidin-3-ol

Frequently Asked Questions

What are the CAS number and molecular formula of Cobimetinib?

CAS 934660-93-2; molecular formula C21H21F3IN3O2; molecular weight — g/mol.

What other names is Cobimetinib known by?

Cobimetinib, 934660-93-2, GDC-0973, XL518, Cotellic, GDC 0973.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.