西立伐他汀

Description

CERIVASTATIN · CAS 145599-86-6 · C26H34FNO5. UNII AM91H2KS67. LogP: 3.4; LogP: 3.26.

Identification

CAS Registry Number	145599-86-6
PubChem CID	446156
Molecular formula	C26H34FNO5
IUPAC name	(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)-3-pyridinyl]-3,5-dihydroxyhept-6-enoic acid
UNII (FDA)	AM91H2KS67

Computed Descriptors

Molecular Weight	459.5
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	459.24210135
Monoisotopic Mass	459.24210135
Topological Polar Surface Area	99.9
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

LogP	3.4
LogP	3.26

Physical description & handling notes

• Highly solubility
• pKa1 = 3.9 (carboxylic acid); pKa2 = 5.4 (pyridine)
• 217.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID0046488]
• 216.3 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID0046488]
• 217.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0046488]
• Mol wt 481.53. Solid, specific optical rotation at 20 °C for D (sodium) line = +24.1 deg (c = 1 in ethanol) /Sodium salt/

Documented Uses

• ... Most effective and best-tolerated agents for treating dyslipidemia. /Statins/
• ... agent that promotes a reduction of lipoprotein levels in the blood.
• Hydroxymethyglutaryl-CoA Reductase Inhibitors
• Prepared and claimed as methyl ester: R. Angerbauer et al., European patent office 325130; eidem, US patent 5006530; as (+)-form sodium salt: eidem, US patent (1989, 1991, 1993 all to Bayer).
• Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate.
• MEDICATION: Antihyperlipoproteinemic

Synonyms

cerivastatin; 145599-86-6; Lipobay; Cerivastatina; AM91H2KS67; CHEBI:3558; (3R,5S,6E)-7-(4-(p-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid; DTXSID9022786; cerivastatinum; RefChem:575215; DTXCID402786; C10AA06; cerivastatin acid; (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoic acid; Cerivastatin (INN); CERIVASTATIN [INN]

Frequently Asked Questions

What are the CAS number and molecular formula of CERIVASTATIN?

CAS 145599-86-6; molecular formula C26H34FNO5; molecular weight — g/mol.

What other names is CERIVASTATIN known by?

cerivastatin, 145599-86-6, Lipobay, Cerivastatina, AM91H2KS67, CHEBI:3558.

What are the key physical properties of CERIVASTATIN?

LogP: 3.4; LogP: 3.26.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.