氯氮平N-氧化物

Description

clozapine N-oxide · CAS 34233-69-7 · C18H19ClN4O. UNII MZA8BK588J.

Identification

CAS Registry Number	34233-69-7
PubChem CID	135445691
Molecular formula	C18H19ClN4O
IUPAC name	3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine
UNII (FDA)	MZA8BK588J

Computed Descriptors

Molecular Weight	342.8
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	342.1247389
Monoisotopic Mass	342.1247389
Topological Polar Surface Area	45.7
Heavy Atom Count	24
Formal Charge	0

GHS Hazard Classification

Reported hazard statements	H301 (100%), H315 (97.5%), H319 (97.5%), H335 (95%)

Documented Uses

• Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
• Clozapine-N-oxide is a known human metabolite of clozapine.

Synonyms

Clozapine N-oxide; 34233-69-7; MZA8BK588J; NSC-750266; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine N-oxide; DTXSID50955778; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine N-Oxide; RefChem:127143; DTXCID201774781; Clozapine (N-oxide); CLOZAPINEN-OXIDE; 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine; CHEMBL1688; 4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide; 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine

Frequently Asked Questions

What are the CAS number and molecular formula of clozapine N-oxide?

CAS 34233-69-7; molecular formula C18H19ClN4O; molecular weight — g/mol.

What other names is clozapine N-oxide known by?

Clozapine N-oxide, 34233-69-7, MZA8BK588J, NSC-750266, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine N-oxide, DTXSID50955778.

Is clozapine N-oxide classified as hazardous?

Hazard statements reported: H301, H315, H319, H335.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.