氢溴酸右美沙芬

Description

dextromethorphan hydrobromide · CAS 125-69-9 · C18H26BrNO. UNII Z0CG3115FG.

Identification

CAS Registry Number	125-69-9
PubChem CID	5464025
Molecular formula	C18H26BrNO
IUPAC name	(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene;hydrobromide
UNII (FDA)	Z0CG3115FG

Computed Descriptors

Molecular Weight	352.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	351.11978
Monoisotopic Mass	351.11978
Topological Polar Surface Area	12.5
Heavy Atom Count	21
Formal Charge	0
Complexity	370

Physical description & handling notes

• 165.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	0.6% (1 / 157)

GHS Hazard Classification

GHS notification summary	0.6% (1 / 157)
Reported hazard statements	H302 (98.7%), H411 (38.9%)

Documented Uses

• The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation (as commonly accompanies the common cold), as well as those resulting from inhaled irritants. In addition, a combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis.
• Breast Feeding; Lactation; Milk, Human; Antitussive Agents
• Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.
• Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
• Sigma-1 Agonist [EPC]; Uncompetitive NMDA Receptor Antagonists [MoA]; Sigma-1 Receptor Agonists [MoA]; Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]
• Sigma-1 Agonist [EPC]; Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]; Uncompetitive NMDA Receptor Antagonists [MoA]; Sigma-1 Receptor Agonists [MoA]

Synonyms

Dextromethorphan hydrobromide; 125-69-9; Delsym; Antussan; Demorphan; Tusilan; d-Methorphan hydrobromide; Romilar; Dextromethorphan bromide; Dextromethorphan HBr; Dextromethorphan polistirex; Dextromethorphan hydrobromide anhydrous; Z0CG3115FG; Benylin DM; CHEBI:4471; DTXSID60872346

Frequently Asked Questions

What are the CAS number and molecular formula of dextromethorphan hydrobromide?

CAS 125-69-9; molecular formula C18H26BrNO; molecular weight — g/mol.

What other names is dextromethorphan hydrobromide known by?

Dextromethorphan hydrobromide, 125-69-9, Delsym, Antussan, Demorphan, Tusilan.

Is dextromethorphan hydrobromide classified as hazardous?

0.6% of GHS notifications report no hazard classification (1 of 157).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.