地氯雷他定

Description

desloratadine · CAS 100643-71-8 · C19H19ClN2. UNII FVF865388R. Solubility: 3.95e-03 g/L; LogP: 3.2; LogP: 2.56.

Identification

CAS Registry Number	100643-71-8
PubChem CID	124087
Molecular formula	C19H19ClN2
IUPAC name	13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
UNII (FDA)	FVF865388R

Computed Descriptors

Molecular Weight	310.8
XLogP3	4.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	310.1236763
Monoisotopic Mass	310.1236763
Topological Polar Surface Area	24.9
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Solubility	3.95e-03 g/L
LogP	3.2
LogP	2.56

Physical description & handling notes

• Solid
• 21.6 [ug/mL] (The mean of the results at pH 7.4)
• 175.5 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H302 (90%), H317 (10%), H318 (85%), H361 (74.3%), H411 (89.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Consumption (g per capita) in the USA (2002): 0.00383
• For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
• Breast Feeding; Lactation; Milk, Human; Antihistamines; Antipruritics; Nonsedating Antihistamines
• Take with or without food. The absorption is unaffected by food.

Synonyms

Desloratadine; 100643-71-8; Clarinex; Aerius; Descarboethoxyloratadine; Desloratidine; Neoclarityn; Azomyr; Sch-34117; Denosin; Opulis; Allex; Sch 34117; 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Desloratadine Actavis; Dasselta

Frequently Asked Questions

What are the CAS number and molecular formula of desloratadine?

CAS 100643-71-8; molecular formula C19H19ClN2; molecular weight — g/mol.

What other names is desloratadine known by?

Desloratadine, 100643-71-8, Clarinex, Aerius, Descarboethoxyloratadine, Desloratidine.

Is desloratadine classified as hazardous?

Hazard statements reported: H302, H317, H318, H361, H411.

What are the key physical properties of desloratadine?

Solubility: 3.95e-03 g/L; LogP: 3.2; LogP: 2.56.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.