达沙替尼

Name: 达沙替尼
Brand: 济南圣和化工有限公司

CAS 302962-49-8C22H26ClN7O2SMW 488.0

达沙替尼，CAS 登记号 302962-49-8，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于医药中间体及原料药。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号302962-49-8

分子式C22H26ClN7O2S

分子量488.0

熔点280-286 °C

LogP1.8

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域医药中间体及原料药

类别医药中间体及原料药

用途与场景

医药中间体及原料药

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

供货周期现货/按订单安排

文件与支持

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常见问题

在哪里能查到达沙替尼的 CAS 号？

本页已列出达沙替尼的 CAS 号：302962-49-8，可与随货 COA 核对。

可以提供哪些规格和包装？

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达沙替尼一般用在什么产品里？

主要涉及医药中间体及原料药。

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PubChem 公开数据

Description

Dasatinib · CAS 302962-49-8 · C22H26ClN7O2S. UNII X78UG0A0RN. Melting Point: 280-286 °C; Melting Point: 280 - 286 °C; Solubility: 1.28e-02 g/L.

Identification

CAS Registry Number	302962-49-8
PubChem CID	3062316
Molecular formula	C22H26ClN7O2S
IUPAC name	N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
UNII (FDA)	X78UG0A0RN

Computed Descriptors

Molecular Weight	488.0
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	487.1557220
Monoisotopic Mass	487.1557220
Topological Polar Surface Area	135
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Melting Point	280-286 °C
Melting Point	280 - 286 °C
Solubility	1.28e-02 g/L
LogP	1.8
LogP	3.41

Physical description & handling notes

Solid

GHS Hazard Classification

Reported hazard statements	H301 (92.5%), H315 (77.5%), H318 (75%), H351 (80%), H360 (12.5%), H361 (80%), H371 (10%), H372 (80%)

H301 (92.5%): Toxic if swallowed [Danger Acute toxicity, oral]

H315 (77.5%): Causes skin irritation [Warning Skin corrosion/irritation]

Documented Uses

Use (kg; approx.) in Germany (2009): >10
Consumption (g per capita; approx.) in Germany (2009): 0.000122
Dasatinib is a selective tyrosine kinase receptor inhibitor that is used in the therapy of chronic myelogenous leukemia (CML) positive for the Philadelphia chromosome. Dasatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.
Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
Oral - Solid: 20 mg tablet; 50 mg tablet; 70 mg tablet; 80 mg tablet; 100 mg tablet; 140 mg tablet
Chronic myeloid leukaemia, not elsewhere classified

Synonyms

Dasatinib; 302962-49-8; Sprycel; BMS-354825; Dasatinib anhydrous; BMS354825; Dasatinib (anhydrous); BMS 354825; dasatinibum; anh. dasatinib; anhydrous dasatinib; dasatinib (anh.); DTXSID4040979; BMS Dasatinib; X78UG0A0RN; NSC732517

Frequently Asked Questions

What are the CAS number and molecular formula of Dasatinib?

CAS 302962-49-8; molecular formula C22H26ClN7O2S; molecular weight — g/mol.

What other names is Dasatinib known by?

Dasatinib, 302962-49-8, Sprycel, BMS-354825, Dasatinib anhydrous, BMS354825.

Is Dasatinib classified as hazardous?

Hazard statements reported: H301, H315, H318, H351, H360.

What are the key physical properties of Dasatinib?

Melting Point: 280-286 °C; Melting Point: 280 - 286 °C; Solubility: 1.28e-02 g/L; LogP: 1.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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