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Doxazosin

CAS 74191-85-8C23H25N5O5MW 451.5

Doxazosin (CAS No. 74191-85-8) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number74191-85-8
Molecular FormulaC23H25N5O5
Molecular Weight451.5
Melting Point275-277
Boiling Point718
LogP2.1
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Doxazosin?

The CAS number of Doxazosin is 74191-85-8.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Doxazosin?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Doxazosin or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Doxazosin · CAS 74191-85-8 · C23H25N5O5. UNII NW1291F1W8. Boiling Point: 718; Melting Point: 275-277; Melting Point: 289 - 290 °C.

Identification

CAS Registry Number74191-85-8
PubChem CID3157
Molecular formulaC23H25N5O5
IUPAC name[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
UNII (FDA)NW1291F1W8

Computed Descriptors

Molecular Weight451.5
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass451.18556891
Monoisotopic Mass451.18556891
Topological Polar Surface Area112
Heavy Atom Count33
Formal Charge0

Physical & Chemical Properties

Boiling Point718
Melting Point275-277
Melting Point289 - 290 °C
Solubility0.8%
Solubility7.90e-01 g/L
LogP2.1
LogP3.38
Dissociation Constants6.52

Physical description & handling notes

  • Solid
  • 202.9 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
  • 196.92 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
  • 200.88 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
  • 199.48 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statementsH302 (20%), H314 (80%), H373 (80%), H411 (80%)

H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (80%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Documented Uses

  • Use (kg; approx.) in Germany (2009): >250
  • Consumption (g per capita; approx.) in Germany (2009): 0.00305
  • Consumption (g per capita) in the USA (2002): 0.00149
  • Doxazosin is indicated to treat the symptoms of benign prostatic hypertrophy, which may include urinary frequency, urgency, and nocturia, among other symptoms. In addition, doxazosin is indicated alone or in combination with various antihypertensive agents for the management of hypertension. Off-label uses of doxazosin include the treatment of pediatric hypertension and the treatment of ureteric calculi.
  • Doxazosin is a nonselective alpha-1 adrenergic antagonist (alpha-blocker) used in the therapy of hypertension and benign prostatic hypertrophy. Doxazosin is associated with a low rate of transient serum aminotransferase elevations, but has not been linked to instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Milk, Human; Adrenergic alpha-Antagonists; Antihypertensive Agents

Synonyms

doxazosin; 74191-85-8; Doxazosine; Doxazosinum; Doxazosina; UK-33274; C02CA04; 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin; CHEBI:4708; UK 33274; 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin; DTXSID7022964; NW1291F1W8; Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-; 2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; (4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHANONE

Frequently Asked Questions

What are the CAS number and molecular formula of Doxazosin?

CAS 74191-85-8; molecular formula C23H25N5O5; molecular weight — g/mol.

What other names is Doxazosin known by?

doxazosin, 74191-85-8, Doxazosine, Doxazosinum, Doxazosina, UK-33274.

Is Doxazosin classified as hazardous?

Hazard statements reported: H302, H314, H373, H411.

What are the key physical properties of Doxazosin?

Boiling Point: 718; Melting Point: 275-277; Melting Point: 289 - 290 °C; Solubility: 0.8%.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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