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右雷佐生

CAS 24584-09-6C11H16N4O4MW 268.27

右雷佐生(CAS 24584-09-6):分子式 C11H16N4O4、分子量 268.27;类别 染料及颜料。

产品描述

右雷佐生(CAS 24584-09-6)是一种染料及颜料原料。其分子式 C11H16N4O4 由 11 个碳、16 个氢、4 个氮、4 个氧 组成。 分子量约为 268.27。公开物性数据显示其熔点约 191-197 °C、LogP 约 -1.4。作为化工品采购代理与分销渠道,我们可在国内及跨境渠道为右雷佐生寻源比价,并安排小批量试样与批次采购;下单前提供完整 COA、质检报告与合规文件,验收以批次 COA 为准。

规格参数

CAS号24584-09-6
分子式C11H16N4O4
分子量268.27
熔点191-197 °C
LogP-1.4
应用领域Cardioprotective agent、For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines、Methods of Manufacturing: Preparation: A. M. Creighton、GB 1234935 eidem、US 3941790 (1971、1976 both to Natl. Res. Dev. Corp.)
类别染料及颜料

用途与场景

登记用途:Cardioprotective agent、For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines、Methods of Manufacturing: Preparation: A. M. Creighton、GB 1234935 eidem、US 3941790 (1971、1976 both to Natl. Res. Dev. Corp.)。

采购档案

这个产品是什么

右雷佐生 是一种着色或颜料类化合物,登记 CAS 号为 24584-09-6,分子式 C11H16N4O4(分子量 268.27),归属于染料及颜料大类化工原料。

识别信息

登记 CAS 号:24584-09-6

其分子式 C11H16N4O4 由 11 个碳、16 个氢、4 个氮、4 个氧 组成。

别名/同义词:右雷佐生 · Dexrazoxane

所属分类:染料及颜料

常见问题

右雷佐生 的 CAS 号是多少?

右雷佐生 的 CAS 登记号为 24584-09-6。

右雷佐生 的分子式与分子量是多少?

分子式 C11H16N4O4,分子量 268.27。

右雷佐生 还有哪些别名?

别名/同义词:右雷佐生、Dexrazoxane。

右雷佐生 的登记用途是什么?

登记用途:Cardioprotective agent、For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines、Methods of Manufacturing: Preparation: A. M. Creighton、GB 1234935 eidem、US 3941790 (1971、1976 both to Natl. Res. Dev. Corp.)。

右雷佐生 属于哪个分类?

所属分类:染料及颜料。

如何在 591daili.cn 采购 右雷佐生?

请在联系页面提交产品名称、CAS 号与数量,我们作为采购代理在国内及跨境渠道为您寻源比价,安排试样与批次采购,下单前提供 COA 与合规文件。

包装与单证

包装按订单确认,从实验室小包装到吨袋大货,随订单安排而非在页面上写死。每批随货附 COA 分析证书,可另提供 MSDS;若终端用途带有法规限度(食品接触、药品或化妆品),请在询价时说明执行标准,等级按该标准确定。

PubChem 公开数据

右雷佐生(CAS 24584-09-6)的公开数据库记录,列此仅供独立核对。

危险化学品分类与危害说明

Reported hazard statementsH315 (97.7%), H319 (97.7%), H335 (95.3%)

H315 (97.7%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (97.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

物理形态与操作说明

  • Solid
  • Crystals from aqueous methanol/ether
  • Whitish crystalline powder
  • Sparingly soluble
  • Slightly soluble in methanol and ethanol. Insoluble in non polar organic solvents.
  • 溶解度 (mg/mL): 35-43 0.1 N HCl, 25-34 0.1 N NaOH, 6.7-10 0.1 M citrate buffer (pH 4), 8.7-13 0.1 M borate buffer (pH 9)

公开数据库收录的理化数据

熔点191-197 °C
熔点193 °C
熔点191 - 197 °C
溶解度In water, 10-12 mg/mL at 25 °C
溶解度1.04e+01 g/L
溶解度H2O 10 - 12 (mg/mL)
溶解度0.1 N HCI 35 - 43 (mg/mL)
溶解度0.1 N NaOH 25 - 34 (mg/mL)
溶解度10% EtOH 6.7 - 10 (mg/mL)
溶解度MeOH 1 (mg/mL)

这个物质在各数据库里的编号

CAS Registry Number24584-09-6
PubChem CID71384
分子式C11H16N4O4
IUPAC 名称4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
UNII(FDA)048L81261F

数据库记载的用途

  • For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.
  • Preparation: A. M. Creighton, GB 1234935 eidem, US 3941790 (1971, 1976 both to Natl. Res. Dev. Corp.)
  • Information available in 2005 indicated that Dexrazoxane was used in the manufacture of pharmaceutical preparations in the following countries: Austria, Brazil, Canada, Czech Republic, Denmark, France, Hungary, Israel, Italy, Mexico, Poland, USA (1,2)
  • Information available in 2005 indicated that Dexrazoxane hydrochloride was used in the manufacture of pharmaceutical preparations in the following countries: Argentina, Brazil, Denmark, France, Hungary, Italy, Poland, Romania, Russian Federation, United States (1) /Dexrazoxane Hydrochloride/
  • Dexrazoxane, an FDA-approved cardioprotective drug, has been successfully used to ameliorate cardiac toxicity seen in anthracycline-based (e.g., doxorubicin, daunorubicin, epirubicin) chemotherapy recipients for cancer, mainly in advanced breast cancer patients, adult patients with soft tissue sarcomas, or small-cell lung cancer. It is used intravenously in conjunction with the anthracycline of choice to decrease the incidence of cardiomyopathy and congestive heart failure.
  • Breast Feeding; Lactation; Antineoplastic Agents; Cardioprotectants; Cardiotonic Agents; Enzyme Inhibitors; Topoisomerase II Inhibitors

它在各数据库里的别名

Dexrazoxane; 24584-09-6; Dextrorazoxane; Dexrazoxano; ICRF-187; Dexrazoxanum; ADR-529; Razoxane, d-; 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione; Razoxane, (s)-; (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione; ADR 529; ICRF 187; (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane; NSC-169780; NSC 169780

计算机算出的分子描述符

分子量268.27
XLogP3-1.4
氢键供体数2
氢键受体数6
可旋转键数3
精确质量268.11715500
单同位素质量268.11715500
拓扑极性表面积98.8
重原子数19
形式电荷0

数据库摘要

Dexrazoxane · CAS 24584-09-6 · C11H16N4O4. UNII 048L81261F. 熔点: 191-197 °C; 熔点: 193 °C; 熔点: 191 - 197 °C.

数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。

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