醋酸地加瑞克

Description

Degarelix acetate · CAS 214766-78-6 · C82H103ClN18O16. UNII SX0XJI3A11.

Identification

CAS Registry Number	214766-78-6
PubChem CID	16136245
Molecular formula	C82H103ClN18O16
UNII (FDA)	SX0XJI3A11

Computed Descriptors

Molecular Weight	1632.3
XLogP3	3.5
Hydrogen Bond Donor Count	17
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	41
Exact Mass	1630.7487970
Monoisotopic Mass	1630.7487970
Topological Polar Surface Area	513
Heavy Atom Count	117
Formal Charge	0

Physical description & handling notes

• White to off-white amorphous powder /Degarelix, acetate anhydrate/
• Table: Degarelix Acetate Preparations [Table#7511]

GHS Hazard Classification

Reported hazard statements	H360 (100%)

Documented Uses

• Intended to treat patients with advanced prostate cancer ... slows the growth and progression of prostate cancer by suppressing testosterone
• THERAPEUTIC CATEGORY: Antineoplastic (hormonal)
• Gonadotropin-releasing hormone (GnRH) antagonist; decapeptide amide with seven unnatural amino acids, five of which are D-amino acids.
• In Canada and the US, degarelix is indicated for the treatment of advanced prostate cancer in patients requiring androgen deprivation therapy. In the EU, it is more specifically indicated for the treatment of adult male patients with advanced hormone-dependent prostate cancer, and for treatment of high-risk localized and locally advanced hormone-dependent prostate cancer, in combination with radiotherapy or as a neo-adjuvant prior to radiotherapy.
• Degarelix is a parenterally administered, gonadotropin releasing hormone (GnRH) antagonist that effectively blocks androgen production and is used to treat advanced prostate cancer. Degarelix therapy is associated with serum enzyme elevations during therapy, but has yet to be linked to instances of clinically apparent acute liver injury.
• Degarelix is approved to treat:

Synonyms

Degarelix; 214766-78-6; SX0XJI3A11; FE-200486 (free base); DTXSID801026401; FE200486 ANHYDROUS FREE BASE; FE-200486 ANHYDROUS FREE BASE; degarelixum; RefChem:58687; L02BX02; DTXCID801510614; Firmagon; CHEMBL415606; FE200486; FE200486 (AS ACETATE SALT); Uglypeptide1

Frequently Asked Questions

What are the CAS number and molecular formula of Degarelix acetate?

CAS 214766-78-6; molecular formula C82H103ClN18O16; molecular weight — g/mol.

What other names is Degarelix acetate known by?

Degarelix, 214766-78-6, SX0XJI3A11, FE-200486 (free base), DTXSID801026401, FE200486 ANHYDROUS FREE BASE.

Is Degarelix acetate classified as hazardous?

Hazard statements reported: H360.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.