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Dolutegravir

CAS 1051375-16-6C20H19F2N3O5MW 419.4

Dolutegravir (CAS No. 1051375-16-6) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1051375-16-6
Molecular FormulaC20H19F2N3O5
Molecular Weight419.4
Melting Point190-193ºC
LogP2.2
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of Dolutegravir?

The CAS number of Dolutegravir is 1051375-16-6.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of Dolutegravir?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy Dolutegravir or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

Dolutegravir · CAS 1051375-16-6 · C20H19F2N3O5. UNII DKO1W9H7M1. Melting Point: 190-193ºC; LogP: 2.2; Dissociation Constants: 8.2.

Identification

CAS Registry Number1051375-16-6
PubChem CID54726191
Molecular formulaC20H19F2N3O5
IUPAC name(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
UNII (FDA)DKO1W9H7M1

Computed Descriptors

Molecular Weight419.4
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass419.12927704
Monoisotopic Mass419.12927704
Topological Polar Surface Area99.2
Heavy Atom Count30
Formal Charge0

Physical & Chemical Properties

Melting Point190-193ºC
LogP2.2
Dissociation Constants8.2

Physical description & handling notes

  • Slightly soluble
  • White to light yellow powder; slightly soluble in water /Dolutegravir sodium/
  • Tivicay Tablets, 50 mg

Regulatory Status

GHS notification summary33.3% (1 / 3)

GHS Hazard Classification

GHS notification summary33.3% (1 / 3)
Reported hazard statementsH400 (66.7%), H410 (66.7%)

This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.

H400 (66.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Documented Uses

  • Preparation: B. A. Johns et al., World Intellectual Property Organization patent 06116764 (2006 to Shionogi); eidem, United States of America patent 090318421 (2009)
  • Dolutegravir is a human immunodeficiency virus (HIV) integrase inhibitor, the third in this class of agents that target the viral integrase. Dolutegravir is used only in combination with other antiretroviral agents in the treatment of HIV infection, and it has had limited use. Dolutegravir is associated with a low rate of serum aminotransferase elevations during therapy, but has not been linked to instances of acute, clinically apparent liver injury.
  • Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antiviral Agents; Anti-HIV Agents; Anti-Retroviral Agents; HIV Integrase Inhibitors
  • Antiretrovirals > Integrase inhibitors
  • Oral - Solid: 50 mg tablet; 10 mg tablet (dispersible, scored)
  • Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified

Synonyms

Dolutegravir; 1051375-16-6; GSK1349572; S/GSK1349572; GSK 1349572; GSK-1349572; S-349572; DKO1W9H7M1; CHEBI:76010; DTXSID90909356; dolutegravirum; RefChem:56964; J05AX12; DTXCID701338419; Tivicay; Dolutegravir (GSK1349572)

Frequently Asked Questions

What are the CAS number and molecular formula of Dolutegravir?

CAS 1051375-16-6; molecular formula C20H19F2N3O5; molecular weight — g/mol.

What other names is Dolutegravir known by?

Dolutegravir, 1051375-16-6, GSK1349572, S/GSK1349572, GSK 1349572, GSK-1349572.

Is Dolutegravir classified as hazardous?

33.3% of GHS notifications report no hazard classification (1 of 3).

What are the key physical properties of Dolutegravir?

Melting Point: 190-193ºC; LogP: 2.2; Dissociation Constants: 8.2.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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