盐酸右雷佐生

Description

Dexrazoxane hydrochloride · CAS 149003-01-0 · C11H17ClN4O4. UNII 5346058Q7S.

Identification

CAS Registry Number	149003-01-0
PubChem CID	6918223
Molecular formula	C11H17ClN4O4
IUPAC name	4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride
UNII (FDA)	5346058Q7S

Computed Descriptors

Molecular Weight	304.73
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	304.0938327
Monoisotopic Mass	304.0938327
Topological Polar Surface Area	98.8
Heavy Atom Count	20
Formal Charge	0
Complexity	404

Documented Uses

• For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.
• Breast Feeding; Lactation; Antineoplastic Agents; Cardioprotectants; Cardiotonic Agents; Enzyme Inhibitors; Topoisomerase II Inhibitors
• Dexrazoxane hydrochloride is approved to treat severe side effects caused by certain types of chemotherapy. It is used to treat the following:
• • Cardiac (heart) side effects caused by doxorubicin hydrochloride in women being treated for metastaticbreast cancer. Dexrazoxane hydrochloride helps make the side effects happen less often and makes them less severe when they do occur. It is used only in women who have already received high doses of doxorubicin and continue to be treated with it. This use is approved for the Totect and Zinecard brands of dexrazoxane hydrochloride.
• • Extravasation caused by intravenousanthracyclines. Extravasation occurs when injecteddrugs leak out of the vein, into surrounding tissue. This can cause redness, pain, and swelling, and may damage the tissue. This use is approved for the Totect brand of dexrazoxane hydrochloride.
• Substances that inhibit or prevent the proliferation of NEOPLASMS.

Synonyms

Dexrazoxane hydrochloride; 149003-01-0; Dexrazoxane HCl; Cardioxane; Totect; Cardioxan; Savene; 1263283-43-7; ADR-529 hydrochloride; ICRF-187 hydrochloride; (+)-Razoxane hydrochloride; Razoxane hydrochloride, (S)-; 2,6-Piperazinedione, 4,4'-((1S)-1-methyl-1,2-ethanediyl)bis-, hydrochloride (1:1); 5346058Q7S; Razoxane (+)-form hydrochloride; DTXSID60164152

Frequently Asked Questions

What are the CAS number and molecular formula of Dexrazoxane hydrochloride?

CAS 149003-01-0; molecular formula C11H17ClN4O4; molecular weight — g/mol.

What other names is Dexrazoxane hydrochloride known by?

Dexrazoxane hydrochloride, 149003-01-0, Dexrazoxane HCl, Cardioxane, Totect, Cardioxan.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.