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dabrafenib mesylate

CAS 1195768-06-9C23H20F3N5O2S2MW 519.6

dabrafenib mesylate (CAS No. 1195768-06-9) is supplied by Jinan Shenghe Chemical Co., Ltd. with a typical purity of 按批次COA提供(不公开发布). Main applications include Pharmaceutical Intermediates & APIs. Bulk quantities are available with COA; purity and packaging are subject to batch COA and order confirmation.

Specifications

CAS Number1195768-06-9
Molecular FormulaC23H20F3N5O2S2
Molecular Weight519.6
Boiling Point653.7
LogP2.9
Purity按批次COA提供(不公开发布)
Packaging按订单/批次确认(不公开发布)
ApplicationsPharmaceutical Intermediates & APIs
CategoryPharmaceutical Intermediates & APIs

Where it is used

Pharmaceutical Intermediates & APIs

Packaging & Supply

Packaging按订单/批次确认(不公开发布)
Purity按批次COA提供(不公开发布)
StorageSealed, cool and dry place
Lead TimeIn stock / per order

Documents & Support

COA provided with every batch; MSDS and technical documents available on request. Email us with product name and CAS number for a quote within one business day.

Frequently Asked Questions

What is the CAS number of dabrafenib mesylate?

The CAS number of dabrafenib mesylate is 1195768-06-9.

What purity and packaging are available?

Typical purity is 按批次COA提供(不公开发布), supplied in 按订单/批次确认(不公开发布), with COA provided.

What are the applications of dabrafenib mesylate?

Main applications include Pharmaceutical Intermediates & APIs.

How do I buy dabrafenib mesylate or get a quote?

Email info@591daili.com or reach us on WhatsApp with the product name, CAS number and required quantity; quotes within one business day. Supplier: Jinan Shenghe Chemical Co., Ltd..

PubChem Public Data

Description

dabrafenib mesylate · CAS 1195768-06-9 · C23H20F3N5O2S2. UNII QGP4HA4G1B. Boiling Point: 653.7; LogP: 2.9; Dissociation Constants: -1.5.

Identification

CAS Registry Number1195768-06-9
PubChem CID44462760
Molecular formulaC23H20F3N5O2S2
IUPAC nameN-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
UNII (FDA)QGP4HA4G1B

Computed Descriptors

Molecular Weight519.6
XLogP34.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count11
Rotatable Bond Count6
Exact Mass519.10105173
Monoisotopic Mass519.10105173
Topological Polar Surface Area147
Heavy Atom Count35
Formal Charge0

Physical & Chemical Properties

Boiling Point653.7
LogP2.9
Dissociation Constants-1.5

Physical description & handling notes

  • very slightly soluble at pH 1

GHS Hazard Classification

Reported hazard statementsH361 (22.2%), H373 (88.9%), H400 (100%), H410 (11.1%), H411 (88.9%)

H361 (22.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361fd (77.8%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]

Documented Uses

  • Dabrafenib is a selective inhibitor of mutated forms of BRAF kinase and is used alone or in combination with trametinib in the treatment of advanced malignant melanoma. Dabrafenib therapy is associated with transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent acute liver injury.
  • Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors;
  • Avoid grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum levels of dabrafenib.
  • Avoid St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce serum levels of dabrafenib.
  • Do not take with or immediately after a high-fat meal. Dabrafenib's bioavailability is reduced when taken with a high-fat meal.
  • Take on an empty stomach. Take dabrafenib at least one hour before or two hours after a meal.

Synonyms

Dabrafenib; 1195765-45-7; GSK2118436A; GSK2118436; GSK-2118436; GSK-2118436A; QGP4HA4G1B; CHEBI:75045; DTXSID20152499; N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; N-(3-(5-(2-AMINOPYRIMIDIN-4-YL)-2-TERT-BUTYL-1,3-THIAZOL-4-YL)-2-FLUOROPHENYL)-2,6-DIFLUOROBENZENESULFONAMIDE; N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; dabrafenibum; RefChem:58040; DTXCID8074990; BRAF Inhibitor GSK2118436

Frequently Asked Questions

What are the CAS number and molecular formula of dabrafenib mesylate?

CAS 1195768-06-9; molecular formula C23H20F3N5O2S2; molecular weight — g/mol.

What other names is dabrafenib mesylate known by?

Dabrafenib, 1195765-45-7, GSK2118436A, GSK2118436, GSK-2118436, GSK-2118436A.

Is dabrafenib mesylate classified as hazardous?

Hazard statements reported: H361, H373, H400, H410, H411.

What are the key physical properties of dabrafenib mesylate?

Boiling Point: 653.7; LogP: 2.9; Dissociation Constants: -1.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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