硬脂酸红霉素

Description

erythromycin stearate · CAS 643-22-1 · C37H67NO13.C18H36O2. UNII LXW024X05M. Melting Point: 212 to 219 °F (NTP, 1992).

Identification

CAS Registry Number	643-22-1
PubChem CID	12559
Molecular formula	C37H67NO13.C18H36O2
IUPAC name	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;octadecanoic acid
UNII (FDA)	LXW024X05M

Computed Descriptors

Molecular Weight	1018.4
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	23
Exact Mass	1017.73277158
Monoisotopic Mass	1017.73277158
Topological Polar Surface Area	231
Heavy Atom Count	71
Formal Charge	0
Complexity	1380

Physical & Chemical Properties

Melting Point	212 to 219 °F (NTP, 1992)

Physical description & handling notes

• Erythromycin stearate appears as fluffy colorless powder or fine white powder. (NTP, 1992)
• CRYSTALS
• WHITE OR SLIGHTLY YELLOW CRYSTALS OR POWDER
• PRACTICALLY ODORLESS
• SLIGHTLY BITTER
• less than 1 mg/mL at 72 °F (NTP, 1992)

Regulatory Status

GHS notification summary	0.9% (1 / 106)

GHS Hazard Classification

GHS notification summary	0.9% (1 / 106)
Reported hazard statements	H317 (59.4%), H319 (39.6%), H334 (59.4%)

Documented Uses

• PREPN OF ERYTHROMCYIN STEARATE (ESTER) IS DESCRIBED IN BOOTH, MURRAY, US PATENT 2,862,921 (1958 TO UPJOHN).
• BY REACTING ERYTHROMYCIN WITH PROPER QUANT OF STEARIC ACID IN ACETONE SOLN & THEN DILUTING SOLN WITH WATER TO PPT SALT.
• Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Dermatologic Agents; Macrolides
• ITS ACTIONS & USES ARE IDENTICAL TO THOSE OF ERYTHROMYCIN.
• ERYTHROMYCIN MAY BE USEFUL FOR DISSEMINATED GONOCOCCAL DISEASE IN PREGNANT PT WHO IS ALLERGIC TO PENICILLIN... 13 PT...TREATED WITH 500 MG OF ERYTHROMYCIN... STEARATE, GIVEN ORALLY EVERY 6 HR FOR 5 DAYS, SHOWED RAPID CLINICAL & BACTERIOLOGICAL RESPONSES.
• MEDICATION (VET): ANTIBACTERIAL AGENT

Synonyms

ERYTHROMYCIN STEARATE; 643-22-1; Abboticine; Bristamycin; Gallimycin; Erypar; Dowmycin E; Wyamycin S; Pfizer-E; Eratrex; Ethril; Meberyt; Erythrocin stearate; Erythromycin octadecanoate (salt); Sk-erythromycin; Ethril 250

Frequently Asked Questions

What are the CAS number and molecular formula of erythromycin stearate?

CAS 643-22-1; molecular formula C37H67NO13.C18H36O2; molecular weight — g/mol.

What other names is erythromycin stearate known by?

ERYTHROMYCIN STEARATE, 643-22-1, Abboticine, Bristamycin, Gallimycin, Erypar.

Is erythromycin stearate classified as hazardous?

0.9% of GHS notifications report no hazard classification (1 of 106).

What are the key physical properties of erythromycin stearate?

Melting Point: 212 to 219 °F (NTP, 1992).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.